Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1259480..1259894 | Replicon | chromosome |
| Accession | NZ_CP045866 | ||
| Organism | Staphylococcus aureus strain CFSAN007894 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | AB466_RS06275 | Protein ID | WP_001065046.1 |
| Coordinates | 1259643..1259894 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AB466_RS06270 | Protein ID | WP_000028424.1 |
| Coordinates | 1259480..1259653 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AB466_RS06210 | 1255044..1255388 | - | 345 | WP_000817289.1 | HNH endonuclease | - |
| AB466_RS06215 | 1255404..1255856 | - | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| AB466_RS06220 | 1255971..1256441 | - | 471 | WP_000282758.1 | hypothetical protein | - |
| AB466_RS06225 | 1256464..1256664 | - | 201 | WP_000265041.1 | DUF1514 family protein | - |
| AB466_RS06230 | 1256664..1257314 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| AB466_RS06235 | 1257473..1257622 | - | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| AB466_RS06240 | 1257619..1258005 | - | 387 | WP_000592201.1 | hypothetical protein | - |
| AB466_RS06245 | 1258002..1258208 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| AB466_RS06250 | 1258205..1258450 | - | 246 | WP_001282074.1 | hypothetical protein | - |
| AB466_RS06255 | 1258487..1259020 | - | 534 | WP_001061838.1 | dUTP diphosphatase | - |
| AB466_RS06260 | 1259035..1259196 | - | 162 | WP_000889682.1 | hypothetical protein | - |
| AB466_RS06265 | 1259197..1259454 | - | 258 | WP_031866878.1 | hypothetical protein | - |
| AB466_RS06270 | 1259480..1259653 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| AB466_RS06275 | 1259643..1259894 | - | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| AB466_RS06280 | 1259909..1260151 | - | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| AB466_RS06285 | 1260155..1260523 | - | 369 | WP_000101270.1 | hypothetical protein | - |
| AB466_RS06290 | 1260536..1260991 | - | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| AB466_RS06295 | 1261000..1261218 | - | 219 | WP_000338527.1 | hypothetical protein | - |
| AB466_RS06300 | 1261225..1262085 | - | 861 | WP_099112241.1 | DnaD domain-containing protein | - |
| AB466_RS06305 | 1262115..1262585 | - | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| AB466_RS06310 | 1262586..1263203 | - | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| AB466_RS06315 | 1263284..1264204 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / sak / hlb / groEL | 1231130..1285145 | 54015 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T142903 WP_001065046.1 NZ_CP045866:c1259894-1259643 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T142903 NZ_CP060899:3659612-3659890 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT142903 WP_000028424.1 NZ_CP045866:c1259653-1259480 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT142903 NZ_CP060899:3659349-3659609 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|