Detailed information of TA system TA142900

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1234761..1235068
• Replicon: chromosome
• Accession: NZ_CP045866
• Organism: Staphylococcus aureus strain CFSAN007894

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: AB466_RS06105
• Protein ID: WP_072353918.1
• Coordinates: 1234892..1235068 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1234761..1234900 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB466_RS06065	1230327..1230506	+	180	WP_000669791.1	hypothetical protein	-
AB466_RS06070	1230817..1231077	+	261	WP_001791826.1	hypothetical protein	-
AB466_RS06075	1231130..1231480	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AB466_RS06080	1231991..1232326	-	336	Protein_1170	SH3 domain-containing protein	-
AB466_RS06085	1232977..1233468	-	492	WP_000920038.1	staphylokinase	-
AB466_RS06090	1233659..1234414	-	756	WP_000861038.1	CHAP domain-containing protein	-
AB466_RS06095	1234426..1234680	-	255	WP_000611512.1	phage holin	-
AB466_RS06100	1234732..1234839	+	108	WP_001791821.1	hypothetical protein	-
-	1234761..1234900	+	140	NuclAT_0	-	Antitoxin
-	1234761..1234900	+	140	NuclAT_0	-	Antitoxin
-	1234761..1234900	+	140	NuclAT_0	-	Antitoxin
-	1234761..1234900	+	140	NuclAT_0	-	Antitoxin
AB466_RS06105	1234892..1235068	-	177	WP_072353918.1	putative holin-like toxin	Toxin
AB466_RS06110	1235211..1235585	-	375	WP_000340977.1	hypothetical protein	-
AB466_RS06115	1235641..1235928	-	288	WP_001262620.1	hypothetical protein	-
AB466_RS06120	1235974..1236126	-	153	WP_001000058.1	hypothetical protein	-
AB466_RS06125	1236119..1239901	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1231130..1285145	54015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T142900 WP_072353918.1 NZ_CP045866:c1235068-1234892 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T142900 NZ_CP060899:c2766710-2766327 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT142900 NZ_CP045866:1234761-1234900 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin