Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1903769..1904240 | Replicon | chromosome |
| Accession | NZ_CP045863 | ||
| Organism | Escherichia coli O157:H7 strain ATCC 43890 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | GIX96_RS09605 | Protein ID | WP_001303511.1 |
| Coordinates | 1903962..1904240 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | GIX96_RS09600 | Protein ID | WP_001302048.1 |
| Coordinates | 1903769..1903960 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GIX96_RS09560 | 1898976..1899560 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| GIX96_RS09565 | 1899617..1900012 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| GIX96_RS09570 | 1900028..1900797 | - | 770 | Protein_1871 | DUF1627 domain-containing protein | - |
| GIX96_RS09575 | 1900823..1901563 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| GIX96_RS09580 | 1901570..1902532 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| GIX96_RS09585 | 1902555..1902980 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| GIX96_RS09590 | 1902977..1903279 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| GIX96_RS09595 | 1903377..1903748 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| GIX96_RS09600 | 1903769..1903960 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| GIX96_RS09605 | 1903962..1904240 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GIX96_RS09610 | 1904593..1904892 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| GIX96_RS09615 | 1904964..1905182 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| GIX96_RS09625 | 1905751..1905939 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| GIX96_RS09630 | 1905936..1906127 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| GIX96_RS09635 | 1906220..1908691 | + | 2472 | WP_000048458.1 | exonuclease | - |
| GIX96_RS09640 | 1908764..1909015 | + | 252 | WP_000005552.1 | excisionase family protein | - |
| GIX96_RS09645 | 1909050..1909234 | + | 185 | Protein_1885 | DUF3596 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleG7' | 1814978..1919120 | 104142 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T142872 WP_001303511.1 NZ_CP045863:1903962-1904240 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T142872 NZ_CP060892:c1903816-1903439 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT142872 WP_001302048.1 NZ_CP045863:1903769-1903960 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT142872 NZ_CP060892:c1904274-1903906 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|