Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2585382..2585880 Replicon chromosome
Accession NZ_CP045854
Organism Agrobacterium sp. MA01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GH983_RS12590 Protein ID WP_153762553.1
Coordinates 2585382..2585576 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GH983_RS12595 Protein ID WP_153762554.1
Coordinates 2585566..2585880 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH983_RS12570 2581440..2582537 + 1098 WP_153762549.1 carboxynorspermidine decarboxylase -
GH983_RS12575 2582588..2583826 + 1239 WP_153762550.1 saccharopine dehydrogenase family protein -
GH983_RS12580 2583993..2584511 + 519 WP_153762551.1 DUF488 domain-containing protein -
GH983_RS12585 2584471..2585277 - 807 WP_153762552.1 hypothetical protein -
GH983_RS12590 2585382..2585576 + 195 WP_153762553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GH983_RS12595 2585566..2585880 + 315 WP_153762554.1 XRE family transcriptional regulator Antitoxin
GH983_RS12600 2585953..2586456 + 504 WP_153762555.1 hypothetical protein -
GH983_RS12605 2586538..2586882 + 345 WP_153762556.1 hypothetical protein -
GH983_RS12610 2586956..2587540 - 585 WP_054151449.1 ATP-dependent Clp protease proteolytic subunit -
GH983_RS12615 2587737..2589083 + 1347 WP_153762557.1 HD-GYP domain-containing protein -
GH983_RS12620 2589256..2590599 + 1344 WP_069043653.1 HD-GYP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2584471..2599340 14869


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-53)

Antitoxin

HigA2-like, helix-turn-helix domain

(27-86)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7482.72 Da        Isoelectric Point: 11.1473

>T142848 WP_153762553.1 NZ_CP045854:2585382-2585576 [Agrobacterium sp. MA01]
MKEIRVRFGKQVWRFAFAFDPSQSAIILCGGDKQGMSQTLFYKSLIRKADTRFSAWLKEKRNGH

Download         Length: 195 bp

>T142848 NZ_CP060885:1119246-1119557 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11600.24 Da        Isoelectric Point: 10.1938

>AT142848 WP_153762554.1 NZ_CP045854:2585566-2585880 [Agrobacterium sp. MA01]
MDTDWKTLRAELPHDVRARLDAKRNERRLGKALAEVRKAMQATQQDVAARAGMTQNTVSKIERADDVLLSSVVRYMRSIG
GGVELVLKTPDGKESRVDLTPEPN

Download         Length: 315 bp

>AT142848 NZ_CP060885:1119554-1119973 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References