Detailed information of TA system TA142848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2585382..2585880
• Replicon: chromosome
• Accession: NZ_CP045854
• Organism: Agrobacterium sp. MA01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GH983_RS12590
• Protein ID: WP_153762553.1
• Coordinates: 2585382..2585576 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GH983_RS12595
• Protein ID: WP_153762554.1
• Coordinates: 2585566..2585880 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH983_RS12570	2581440..2582537	+	1098	WP_153762549.1	carboxynorspermidine decarboxylase	-
GH983_RS12575	2582588..2583826	+	1239	WP_153762550.1	saccharopine dehydrogenase family protein	-
GH983_RS12580	2583993..2584511	+	519	WP_153762551.1	DUF488 domain-containing protein	-
GH983_RS12585	2584471..2585277	-	807	WP_153762552.1	hypothetical protein	-
GH983_RS12590	2585382..2585576	+	195	WP_153762553.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH983_RS12595	2585566..2585880	+	315	WP_153762554.1	XRE family transcriptional regulator	Antitoxin
GH983_RS12600	2585953..2586456	+	504	WP_153762555.1	hypothetical protein	-
GH983_RS12605	2586538..2586882	+	345	WP_153762556.1	hypothetical protein	-
GH983_RS12610	2586956..2587540	-	585	WP_054151449.1	ATP-dependent Clp protease proteolytic subunit	-
GH983_RS12615	2587737..2589083	+	1347	WP_153762557.1	HD-GYP domain-containing protein	-
GH983_RS12620	2589256..2590599	+	1344	WP_069043653.1	HD-GYP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2584471..2599340	14869

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (1-53)

Antitoxin

• HigA2-like, helix-turn-helix domain (27-86)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7482.72 Da
• Isoelectric Point: 11.1473

>T142848 WP_153762553.1 NZ_CP045854:2585382-2585576 [Agrobacterium sp. MA01]
MKEIRVRFGKQVWRFAFAFDPSQSAIILCGGDKQGMSQTLFYKSLIRKADTRFSAWLKEKRNGH

Nucleotide

• Length: 195 bp

>T142848 NZ_CP060885:1119246-1119557 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11600.24 Da
• Isoelectric Point: 10.1938

>AT142848 WP_153762554.1 NZ_CP045854:2585566-2585880 [Agrobacterium sp. MA01]
MDTDWKTLRAELPHDVRARLDAKRNERRLGKALAEVRKAMQATQQDVAARAGMTQNTVSKIERADDVLLSSVVRYMRSIG
GGVELVLKTPDGKESRVDLTPEPN

Nucleotide

• Length: 315 bp

>AT142848 NZ_CP060885:1119554-1119973 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA