Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1703043..1703703 Replicon chromosome
Accession NZ_CP045845
Organism Kluyvera intermedia strain N2-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GHC21_RS07860 Protein ID WP_153742586.1
Coordinates 1703043..1703396 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GHC21_RS07865 Protein ID WP_153742587.1
Coordinates 1703401..1703703 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC21_RS07850 1699541..1699972 + 432 WP_153742584.1 universal stress protein -
GHC21_RS07855 1700020..1702710 + 2691 WP_153742585.1 cation-transporting P-type ATPase -
GHC21_RS07860 1703043..1703396 + 354 WP_153742586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHC21_RS07865 1703401..1703703 + 303 WP_153742587.1 XRE family transcriptional regulator Antitoxin
GHC21_RS07870 1704047..1704409 + 363 WP_153742588.1 helix-turn-helix transcriptional regulator -
GHC21_RS07875 1704552..1705337 - 786 WP_153742589.1 SDR family oxidoreductase -
GHC21_RS07880 1705473..1705958 - 486 WP_153742590.1 NAD(P)-binding domain-containing protein -
GHC21_RS07885 1706047..1707504 - 1458 WP_153742591.1 efflux transporter outer membrane subunit -
GHC21_RS07890 1707594..1708208 + 615 WP_013575227.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13395.31 Da        Isoelectric Point: 6.2818

>T142831 WP_153742586.1 NZ_CP045845:1703043-1703396 [Kluyvera intermedia]
VWTIKTTDGFDNWFSTLCATDRASVLALLIVLWEKGPGLPRLYADRIKGSCYSNMKELRVQSQGDPIRVFFAFDPYRTGI
LLCAGNKVGNEKRFYNQMIAVADREFTDYLNTLDDKE

Download         Length: 354 bp

>T142831 NZ_CP060880:2409071-2410393 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11094.83 Da        Isoelectric Point: 4.9001

>AT142831 WP_153742587.1 NZ_CP045845:1703401-1703703 [Kluyvera intermedia]
MGRTLEELLADEKPDVVADAQAMAADILLNIHLAELREKVQKTQVEMAEVLGIRQPTVASMEKPGRDMKLSTLKRYVEAT
GGKLRFDVELPDGSHYGFVL

Download         Length: 303 bp

>AT142831 NZ_CP060880:2408805-2409071 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References