Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4531239..4531903 | Replicon | chromosome |
Accession | NZ_CP045837 | ||
Organism | Citrobacter sp. H12-3-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | GHC22_RS21560 | Protein ID | WP_032942116.1 |
Coordinates | 4531601..4531903 (-) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A5A9BY49 |
Locus tag | GHC22_RS21555 | Protein ID | WP_008786950.1 |
Coordinates | 4531239..4531580 (-) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GHC22_RS21525 | 4526742..4527500 | + | 759 | WP_003844769.1 | phosphonate C-P lyase system protein PhnK | - |
GHC22_RS21530 | 4527622..4528308 | + | 687 | WP_003826708.1 | phosphonate C-P lyase system protein PhnL | - |
GHC22_RS21535 | 4528305..4529441 | + | 1137 | WP_103015272.1 | alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase | - |
GHC22_RS21540 | 4529444..4529998 | + | 555 | WP_008786953.1 | ribose 1,5-bisphosphokinase | - |
GHC22_RS21545 | 4529985..4530419 | + | 435 | WP_008786952.1 | aminoalkylphosphonate N-acetyltransferase | - |
GHC22_RS21550 | 4530428..4531186 | + | 759 | WP_153753882.1 | phosphonate metabolism protein PhnP | - |
GHC22_RS21555 | 4531239..4531580 | - | 342 | WP_008786950.1 | HigA family addiction module antidote protein | Antitoxin |
GHC22_RS21560 | 4531601..4531903 | - | 303 | WP_032942116.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GHC22_RS21565 | 4532060..4532389 | - | 330 | WP_153753883.1 | hypothetical protein | - |
GHC22_RS21570 | 4532459..4534723 | - | 2265 | WP_153753884.1 | hybrid sensor histidine kinase/response regulator | - |
GHC22_RS21575 | 4534838..4536361 | + | 1524 | WP_153753885.1 | sugar ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11860.49 Da Isoelectric Point: 9.9581
>T142791 WP_032942116.1 NZ_CP045837:c4531903-4531601 [Citrobacter sp. H12-3-2]
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY
Download Length: 303 bp
>T142791 NZ_CP060867:c4488611-4488504 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12986.83 Da Isoelectric Point: 6.4743
>AT142791 WP_008786950.1 NZ_CP045837:c4531580-4531239 [Citrobacter sp. H12-3-2]
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA
Download Length: 342 bp
>AT142791 NZ_CP060867:4488659-4488725 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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