Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4531239..4531903 Replicon chromosome
Accession NZ_CP045837
Organism Citrobacter sp. H12-3-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GHC22_RS21560 Protein ID WP_032942116.1
Coordinates 4531601..4531903 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5A9BY49
Locus tag GHC22_RS21555 Protein ID WP_008786950.1
Coordinates 4531239..4531580 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHC22_RS21525 4526742..4527500 + 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -
GHC22_RS21530 4527622..4528308 + 687 WP_003826708.1 phosphonate C-P lyase system protein PhnL -
GHC22_RS21535 4528305..4529441 + 1137 WP_103015272.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
GHC22_RS21540 4529444..4529998 + 555 WP_008786953.1 ribose 1,5-bisphosphokinase -
GHC22_RS21545 4529985..4530419 + 435 WP_008786952.1 aminoalkylphosphonate N-acetyltransferase -
GHC22_RS21550 4530428..4531186 + 759 WP_153753882.1 phosphonate metabolism protein PhnP -
GHC22_RS21555 4531239..4531580 - 342 WP_008786950.1 HigA family addiction module antidote protein Antitoxin
GHC22_RS21560 4531601..4531903 - 303 WP_032942116.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHC22_RS21565 4532060..4532389 - 330 WP_153753883.1 hypothetical protein -
GHC22_RS21570 4532459..4534723 - 2265 WP_153753884.1 hybrid sensor histidine kinase/response regulator -
GHC22_RS21575 4534838..4536361 + 1524 WP_153753885.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11860.49 Da        Isoelectric Point: 9.9581

>T142791 WP_032942116.1 NZ_CP045837:c4531903-4531601 [Citrobacter sp. H12-3-2]
MSKSLNIRNFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

>T142791 NZ_CP060867:c4488611-4488504 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12986.83 Da        Isoelectric Point: 6.4743

>AT142791 WP_008786950.1 NZ_CP045837:c4531580-4531239 [Citrobacter sp. H12-3-2]
MKQASRKPTTVGDILQYEYLEPLDLKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRDVGAKKVA

Download         Length: 342 bp

>AT142791 NZ_CP060867:4488659-4488725 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BY49

References