Detailed information of TA system TA142748

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2601953..2602324
• Replicon: chromosome
• Accession: NZ_CP045827
• Organism: Escherichia coli strain AUSMDU00014361

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: GIJ02_RS13390
• Protein ID: WP_001443846.1
• Coordinates: 2602175..2602324 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2601953..2602131 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GIJ02_RS13365	2597908..2599281	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
GIJ02_RS13370	2599410..2600345	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
GIJ02_RS13375	2600397..2601632	-	1236	WP_000040839.1	site-specific integrase	-
GIJ02_RS13380	2601634..2601849	-	216	WP_000079604.1	excisionase XisR	-
GIJ02_RS13385	2601949..2602137	-	189	WP_001302840.1	DUF1187 family protein	-
-	2601953..2602131	+	179	NuclAT_0	-	Antitoxin
-	2601953..2602131	+	179	NuclAT_0	-	Antitoxin
-	2601953..2602131	+	179	NuclAT_0	-	Antitoxin
-	2601953..2602131	+	179	NuclAT_0	-	Antitoxin
GIJ02_RS13390	2602175..2602324	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
GIJ02_RS13395	2602380..2603189	-	810	WP_000166313.1	recombination protein RecT	-
GIJ02_RS13400	2603182..2605782	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
GIJ02_RS13405	2605884..2606159	-	276	WP_001344816.1	hypothetical protein	-
GIJ02_RS13410	2606234..2606404	-	171	WP_001352098.1	conserved protein, Rac prophage	-
GIJ02_RS13415	2606404..2606625	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2600397..2646725	46328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T142748 WP_001443846.1 NZ_CP045827:c2602324-2602175 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T142748 NZ_CP060852:3372635-3372853 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT142748 NZ_CP045827:2601953-2602131 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin