Detailed information of TA system TA142678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-SR6/-
• Location: 2305893..2306182
• Replicon: chromosome
• Accession: NZ_CP045820
• Organism: Bacillus subtilis strain MB9_B1

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: GII81_RS11825
• Protein ID: WP_009967548.1
• Coordinates: 2305893..2306009 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	SR6
Locus tag	-
Coordinates	2306004..2306182 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII81_RS11795	2301353..2302591	-	1239	WP_142743355.1	MFS transporter	-
GII81_RS11800	2302704..2303954	-	1251	WP_153912306.1	UV damage repair protein UvrX	-
GII81_RS11805	2303947..2304279	-	333	WP_128473977.1	YolD-like family protein	-
GII81_RS11810	2304453..2304788	+	336	WP_004399073.1	hypothetical protein	-
GII81_RS11815	2304831..2305187	-	357	WP_019712874.1	hypothetical protein	-
GII81_RS11820	2305193..2305660	-	468	WP_128992107.1	DUF4879 domain-containing protein	-
GII81_RS11825	2305893..2306009	+	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
-	2306004..2306182	-	179	NuclAT_1	-	Antitoxin
-	2306004..2306182	-	179	NuclAT_1	-	Antitoxin
-	2306004..2306182	-	179	NuclAT_1	-	Antitoxin
-	2306004..2306182	-	179	NuclAT_1	-	Antitoxin
GII81_RS11830	2306633..2307109	-	477	WP_080316884.1	SMI1/KNR4 family protein	-
GII81_RS11835	2307210..2307698	-	489	WP_041056186.1	antitoxin YezG family protein	-
GII81_RS11840	2307705..2309615	-	1911	WP_153912308.1	ribonuclease YeeF family protein	-
GII81_RS11845	2309715..2310272	-	558	WP_153912309.1	SMI1/KNR4 family protein	-
GII81_RS11850	2310338..2310591	-	254	Protein_2284	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2179320..2341013	161693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T142678 WP_009967548.1 NZ_CP045820:2305893-2306009 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T142678 NZ_CP060819:176191-176658 [Pantoea ananatis]
TTGAAGCTCTATCGCATGACCAAAACGCGCTATCTGGGGTCGGCCTGGAGCGGTTTTGGTGCCCGCGAAGGCGGCGGGCG
CTGGAACAGCGTCGGCGTATCAATGGTTTACGCTTCTGAAACCGCTTCCCTCACCATGCTAGAGACGCTTATCCATCTGC
AAAGCGCCAGCGTGCTGGACTGTTTTACCCTCATGAGCATTGACGTTCCCGACAGGCTGATTGAATGGATCGATATCAAG
CAACTTCCTGACGACTGGGCCGCACCGGAAGCGCCTGCAGCGCTGCGTTTATTTGGTGATGCCTGGATACAAAGCGGGGG
ATCGGTCGCACTGCGCGTGCCCAGCGCCCTTTCGCCCGTAGAGTCGAATTATCTTCTCAATCCGGAACATCCCGAATTCA
ATGCTATCGTCAGACAGGCGGTAAACATCCCCTTCCTTTTTGACGTACGCTTCTCCCGACAGGCATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT142678 NZ_CP045820:c2306182-2306004 [Bacillus subtilis]
AATGATACAAATAATTATTTTTTGCATTTTGATTTGTAGAAATGCATAAAATAAAAAGACCAGGGTGCTACCAACACCCC
AGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCAGATGTATGTGACATAGTAGACCAACCCTTTAGGGTCGCAAT
CTCAAGGGGAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin