Detailed information of TA system TA142656

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2493984..2494309
• Replicon: chromosome
• Accession: NZ_CP045816
• Organism: Bacillus subtilis strain P5_B2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: GII86_RS13345
• Protein ID: WP_004398662.1
• Coordinates: 2493984..2494163 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2494087..2494309 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GII86_RS13335	2493210..2493347	-	138	WP_021480099.1	hypothetical protein	-
GII86_RS13340	2493389..2493838	-	450	WP_032722171.1	phage portal protein	-
GII86_RS13345	2493984..2494163	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2494087..2494309	-	223	NuclAT_0	-	Antitoxin
-	2494087..2494309	-	223	NuclAT_0	-	Antitoxin
-	2494087..2494309	-	223	NuclAT_0	-	Antitoxin
-	2494087..2494309	-	223	NuclAT_0	-	Antitoxin
GII86_RS13350	2494543..2494632	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
GII86_RS13355	2494886..2495329	-	444	WP_003229930.1	phage tail tube protein	-
GII86_RS13360	2495332..2496732	-	1401	WP_003229929.1	phage tail sheath family protein	-
GII86_RS13365	2496733..2496924	-	192	WP_010886574.1	hypothetical protein	-
GII86_RS13370	2496921..2497358	-	438	WP_046160618.1	hypothetical protein	-
GII86_RS13375	2497371..2497874	-	504	WP_015714316.1	HK97 gp10 family phage protein	-
GII86_RS13380	2497871..2498233	-	363	WP_015714317.1	YqbH/XkdH family protein	-
GII86_RS13385	2498230..2498625	-	396	WP_015714318.1	DUF3199 family protein	-
GII86_RS13390	2498630..2498941	-	312	WP_015714319.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2463404..2543811	80407

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T142656 WP_004398662.1 NZ_CP045816:2493984-2494163 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T142656 NZ_CP060809:c21234-20950 [Klebsiella variicola]
ATGACCAGAAAAAGGGAAATTGAATACTCAGGACAGTTTCAGAAAGATGTGAAGAAAGCTCAGAAGCGTAATAAGGACAT
GGCAAAGCTAAAAACCCTTATTACGCTCTTAATTGAAGATAAGCTACCGTTACCAGCAATATATAAAGATCACCCGTTAC
AAGGTGATTATAAAGGTTACAGGGATGCACATATCGAGCCTGATTGGTTATTGATTTACAAAATTTCAGATACCAAACTT
CGTTTTGAACGTACAGGCACACATTCAGATCTGTTTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT142656 NZ_CP045816:c2494309-2494087 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin