Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 819004..819764 | Replicon | chromosome |
Accession | NZ_CP045771 | ||
Organism | Citrobacter braakii strain MiY-A |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7L6U900 |
Locus tag | GFC06_RS03730 | Protein ID | WP_019077936.1 |
Coordinates | 819004..819315 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GFC06_RS03735 | Protein ID | WP_103767199.1 |
Coordinates | 819312..819764 (+) | Length | 151 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GFC06_RS03700 | 814672..815574 | + | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
GFC06_RS03705 | 815571..816206 | + | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
GFC06_RS03710 | 816203..817132 | + | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
GFC06_RS03715 | 817169..817543 | - | 375 | WP_016155182.1 | type II toxin-antitoxin system VapC family toxin | - |
GFC06_RS03720 | 817543..817785 | - | 243 | WP_016155181.1 | ribbon-helix-helix domain-containing protein | - |
GFC06_RS03725 | 817990..818919 | + | 930 | WP_047497507.1 | alpha/beta hydrolase | - |
GFC06_RS03730 | 819004..819315 | + | 312 | WP_019077936.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
GFC06_RS03735 | 819312..819764 | + | 453 | WP_103767199.1 | helix-turn-helix domain-containing protein | Antitoxin |
GFC06_RS03740 | 819782..820723 | - | 942 | WP_049282313.1 | fatty acid biosynthesis protein FabY | - |
GFC06_RS03745 | 820768..821205 | - | 438 | WP_003028671.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
GFC06_RS03750 | 821202..822074 | - | 873 | WP_019077938.1 | virulence factor BrkB family protein | - |
GFC06_RS03755 | 822068..822667 | - | 600 | WP_016155174.1 | glucose-1-phosphatase | - |
GFC06_RS03760 | 822772..823575 | - | 804 | WP_016155173.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
GFC06_RS03765 | 823609..824505 | - | 897 | WP_141876131.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12502.67 Da Isoelectric Point: 9.9988
>T142516 WP_019077936.1 NZ_CP045771:819004-819315 [Citrobacter braakii]
MHVISRKPFNEAILRFPNHMAALVDLLNILEKKMFHTPEEMKQYIPSLDNFKYRNKWWVINVSGNCLRLIAYIDFKLQKV
FVKHIVHHAEYDRLTTYYRGHKE
MHVISRKPFNEAILRFPNHMAALVDLLNILEKKMFHTPEEMKQYIPSLDNFKYRNKWWVINVSGNCLRLIAYIDFKLQKV
FVKHIVHHAEYDRLTTYYRGHKE
Download Length: 312 bp
>T142516 NZ_CP060709:c3201101-3200694 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 17007.40 Da Isoelectric Point: 6.1420
>AT142516 WP_103767199.1 NZ_CP045771:819312-819764 [Citrobacter braakii]
MRTHESHHIDTASVKLMIDTFTDAVKKIPLLGKEQNETEYRKALALVEFLVDRDDLENPLFELLSARIRDYEKHAPEFSA
LNQQLEHTPHGVALLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVSHIKMLAERFNLPADAFIE
MRTHESHHIDTASVKLMIDTFTDAVKKIPLLGKEQNETEYRKALALVEFLVDRDDLENPLFELLSARIRDYEKHAPEFSA
LNQQLEHTPHGVALLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVSHIKMLAERFNLPADAFIE
Download Length: 453 bp
>AT142516 NZ_CP060709:c3201348-3201082 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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