Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 819004..819764 Replicon chromosome
Accession NZ_CP045771
Organism Citrobacter braakii strain MiY-A

Toxin (Protein)


Gene name higB Uniprot ID A0A7L6U900
Locus tag GFC06_RS03730 Protein ID WP_019077936.1
Coordinates 819004..819315 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GFC06_RS03735 Protein ID WP_103767199.1
Coordinates 819312..819764 (+) Length 151 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFC06_RS03700 814672..815574 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
GFC06_RS03705 815571..816206 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
GFC06_RS03710 816203..817132 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
GFC06_RS03715 817169..817543 - 375 WP_016155182.1 type II toxin-antitoxin system VapC family toxin -
GFC06_RS03720 817543..817785 - 243 WP_016155181.1 ribbon-helix-helix domain-containing protein -
GFC06_RS03725 817990..818919 + 930 WP_047497507.1 alpha/beta hydrolase -
GFC06_RS03730 819004..819315 + 312 WP_019077936.1 type II toxin-antitoxin system HigB family toxin Toxin
GFC06_RS03735 819312..819764 + 453 WP_103767199.1 helix-turn-helix domain-containing protein Antitoxin
GFC06_RS03740 819782..820723 - 942 WP_049282313.1 fatty acid biosynthesis protein FabY -
GFC06_RS03745 820768..821205 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
GFC06_RS03750 821202..822074 - 873 WP_019077938.1 virulence factor BrkB family protein -
GFC06_RS03755 822068..822667 - 600 WP_016155174.1 glucose-1-phosphatase -
GFC06_RS03760 822772..823575 - 804 WP_016155173.1 DeoR/GlpR family DNA-binding transcription regulator -
GFC06_RS03765 823609..824505 - 897 WP_141876131.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12502.67 Da        Isoelectric Point: 9.9988

>T142516 WP_019077936.1 NZ_CP045771:819004-819315 [Citrobacter braakii]
MHVISRKPFNEAILRFPNHMAALVDLLNILEKKMFHTPEEMKQYIPSLDNFKYRNKWWVINVSGNCLRLIAYIDFKLQKV
FVKHIVHHAEYDRLTTYYRGHKE

Download         Length: 312 bp

>T142516 NZ_CP060709:c3201101-3200694 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 17007.40 Da        Isoelectric Point: 6.1420

>AT142516 WP_103767199.1 NZ_CP045771:819312-819764 [Citrobacter braakii]
MRTHESHHIDTASVKLMIDTFTDAVKKIPLLGKEQNETEYRKALALVEFLVDRDDLENPLFELLSARIRDYEKHAPEFSA
LNQQLEHTPHGVALLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVSHIKMLAERFNLPADAFIE

Download         Length: 453 bp

>AT142516 NZ_CP060709:c3201348-3201082 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7L6U900


Antitoxin

Source ID Structure

References