Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 852894..853498 Replicon chromosome
Accession NZ_CP045767
Organism Pseudomonas sp. CFSAN084952

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GH769_RS03965 Protein ID WP_032903171.1
Coordinates 853184..853498 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GH769_RS03960 Protein ID WP_014717446.1
Coordinates 852894..853181 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH769_RS03925 848398..849156 + 759 WP_014717370.1 MBL fold metallo-hydrolase -
GH769_RS03930 849184..849897 + 714 WP_005786030.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
GH769_RS03940 850166..850459 - 294 Protein_774 type II toxin-antitoxin system RelE/ParE family toxin -
GH769_RS03945 850449..850688 - 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GH769_RS03950 851095..851349 + 255 WP_032903173.1 hypothetical protein -
GH769_RS03955 851422..852648 - 1227 WP_014717445.1 MFS transporter -
GH769_RS03960 852894..853181 - 288 WP_014717446.1 helix-turn-helix domain-containing protein Antitoxin
GH769_RS03965 853184..853498 - 315 WP_032903171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GH769_RS03970 853605..854546 - 942 WP_014717448.1 LysR family transcriptional regulator -
GH769_RS03975 854704..856020 + 1317 WP_032903170.1 MHS family MFS transporter -
GH769_RS03980 856032..857264 + 1233 WP_019818457.1 Zn-dependent hydrolase -
GH769_RS03985 857399..858451 + 1053 WP_019818455.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11676.43 Da        Isoelectric Point: 9.8054

>T142492 WP_032903171.1 NZ_CP045767:c853498-853184 [Pseudomonas sp. CFSAN084952]
MIFIETSVFTRRVKELIDEDAYTAFQNVLVVNPAAGDVIEGTGGIRKIRVAAKSHGKRGGARVIYYHFASASQIVLLMIY
PKNEQQDLSADERKSLKAAIEHWR

Download         Length: 315 bp

>T142492 NZ_CP060708:c3219187-3218873 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10794.39 Da        Isoelectric Point: 7.3219

>AT142492 WP_014717446.1 NZ_CP045767:c853181-852894 [Pseudomonas sp. CFSAN084952]
MSRLFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp

>AT142492 NZ_CP060708:c3218876-3218460 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References