Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
Location | 852894..853498 | Replicon | chromosome |
Accession | NZ_CP045767 | ||
Organism | Pseudomonas sp. CFSAN084952 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | GH769_RS03965 | Protein ID | WP_032903171.1 |
Coordinates | 853184..853498 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | GH769_RS03960 | Protein ID | WP_014717446.1 |
Coordinates | 852894..853181 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GH769_RS03925 | 848398..849156 | + | 759 | WP_014717370.1 | MBL fold metallo-hydrolase | - |
GH769_RS03930 | 849184..849897 | + | 714 | WP_005786030.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
GH769_RS03940 | 850166..850459 | - | 294 | Protein_774 | type II toxin-antitoxin system RelE/ParE family toxin | - |
GH769_RS03945 | 850449..850688 | - | 240 | WP_014717442.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
GH769_RS03950 | 851095..851349 | + | 255 | WP_032903173.1 | hypothetical protein | - |
GH769_RS03955 | 851422..852648 | - | 1227 | WP_014717445.1 | MFS transporter | - |
GH769_RS03960 | 852894..853181 | - | 288 | WP_014717446.1 | helix-turn-helix domain-containing protein | Antitoxin |
GH769_RS03965 | 853184..853498 | - | 315 | WP_032903171.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GH769_RS03970 | 853605..854546 | - | 942 | WP_014717448.1 | LysR family transcriptional regulator | - |
GH769_RS03975 | 854704..856020 | + | 1317 | WP_032903170.1 | MHS family MFS transporter | - |
GH769_RS03980 | 856032..857264 | + | 1233 | WP_019818457.1 | Zn-dependent hydrolase | - |
GH769_RS03985 | 857399..858451 | + | 1053 | WP_019818455.1 | histone deacetylase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11676.43 Da Isoelectric Point: 9.8054
>T142492 WP_032903171.1 NZ_CP045767:c853498-853184 [Pseudomonas sp. CFSAN084952]
MIFIETSVFTRRVKELIDEDAYTAFQNVLVVNPAAGDVIEGTGGIRKIRVAAKSHGKRGGARVIYYHFASASQIVLLMIY
PKNEQQDLSADERKSLKAAIEHWR
MIFIETSVFTRRVKELIDEDAYTAFQNVLVVNPAAGDVIEGTGGIRKIRVAAKSHGKRGGARVIYYHFASASQIVLLMIY
PKNEQQDLSADERKSLKAAIEHWR
Download Length: 315 bp
>T142492 NZ_CP060708:c3219187-3218873 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10794.39 Da Isoelectric Point: 7.3219
>AT142492 WP_014717446.1 NZ_CP045767:c853181-852894 [Pseudomonas sp. CFSAN084952]
MSRLFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS
MSRLFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS
Download Length: 288 bp
>AT142492 NZ_CP060708:c3218876-3218460 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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