142441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1765246..1765939 Replicon chromosome
Accession NZ_CP045741
Organism Escherichia coli strain DH5alpha

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GHR40_RS08435 Protein ID WP_000415584.1
Coordinates 1765246..1765542 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GHR40_RS08440 Protein ID WP_000650107.1
Coordinates 1765544..1765939 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHR40_RS08400 1760334..1760648 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
GHR40_RS08405 1760679..1761260 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GHR40_RS08410 1761579..1761911 + 333 WP_000917684.1 DUF2645 family protein -
GHR40_RS08415 1761957..1763306 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GHR40_RS08420 1763303..1763962 - 660 WP_001221495.1 two-component system response regulator QseB -
GHR40_RS08425 1764114..1764506 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GHR40_RS08430 1764559..1765041 + 483 WP_000183505.1 transcriptional regulator -
GHR40_RS08435 1765246..1765542 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GHR40_RS08440 1765544..1765939 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GHR40_RS08445 1766072..1767679 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GHR40_RS08450 1767817..1770075 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T142441 WP_000415584.1 NZ_CP045741:1765246-1765542 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T142441 NZ_CP060694:c1246124-1245840 [Aliarcobacter cryaerophilus]
ATGAGTTACTTTCTTGATTTTCATCCGAAAGCTTTAAAAGAGTGGAAAAATCTTAATCAATCTTTAAAGATACAGTTTCA
TAAAAAACTAAAAGAACGACTTGAAAATCCAAGAGTGTCAAAAGATAAATTAAGTGGATATGAAAATGTTTATAAAATAA
AATTAAGAAGTTCTGGTTTTAGACTTGCTTATGAGGTTAAAGATTTGGAGATAATAGTATATGTTGTAAGTGTTGGTAAG
AGAGAAAATAATAAAGTGTATGAAAATTTGAAAGATAGAATATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT142441 WP_000650107.1 NZ_CP045741:1765544-1765939 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT142441 NZ_CP060694:c1246365-1246108 [Aliarcobacter cryaerophilus]
ATGCAACCAATATTAGCAAACTATACAGCAAGTATAACCGAACTTAAAAAATCACCAACTCAACTACTCAAAGATGCTGG
AGATGAAGCAATAGCTATACTCAATCATAATGTAGCTTCTGCTTATTTAGTTCCAGCAAGTTTGTATGAAAAGATGATGG
AAGTTATGGATGATTACTACCTAAGCAAAGAAGTTGAGGAAAGACTTAAAGACAATAAAAAACCAATAAGAGTAGAGCTA
GATGAGTTACTTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References