Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1233696..1233918 Replicon chromosome
Accession NZ_CP045741
Organism Escherichia coli strain DH5alpha

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag GHR40_RS05850 Protein ID WP_000141634.1
Coordinates 1233811..1233918 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1233696..1233762 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHR40_RS05830 1229137..1230039 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
GHR40_RS05835 1230050..1231033 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
GHR40_RS05840 1231030..1232034 + 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
GHR40_RS05845 1232064..1233335 - 1272 WP_001295225.1 transporter -
- 1233696..1233762 - 67 - - Antitoxin
GHR40_RS05850 1233811..1233918 + 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
GHR40_RS05855 1234005..1235684 - 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
GHR40_RS05860 1235681..1235872 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
GHR40_RS05865 1235869..1237440 - 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
GHR40_RS05870 1237713..1237901 + 189 WP_001063318.1 YhjR family protein -
GHR40_RS05875 1237913..1238665 + 753 Protein_1128 cellulose biosynthesis protein BcsQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T142437 WP_000141634.1 NZ_CP045741:1233811-1233918 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T142437 NZ_CP060693:1182786-1183052 [Aliarcobacter cryaerophilus]
ATGGTAAACTATAAACTTGTTTATACTAAACAAGCTGGAAAAGATGCTAAGAAATTATCTAGTTCAGGCTTAAAATCAAA
GGCTTTGGAATTATTAGAGATAATTTCTTTAAATCCATATCAAAATCCCCCGCCTTATGAAAAACTAATTGGTGATTTAA
ATAGTGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTG
ATACGAATGTGGTCACATTATGAGTAA

Antitoxin


Download         Length: 67 bp

>AT142437 NZ_CP045741:c1233762-1233696 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References