Detailed information of TA system TA142392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 24049..24551
• Replicon: plasmid pEuc2
• Accession: NZ_CP045722
• Organism: Pantoea eucalypti strain LMG 24197

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EE896_RS21385
• Protein ID: WP_140034217.1
• Coordinates: 24049..24303 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: E0M3B7
• Locus tag: EE896_RS21390
• Protein ID: WP_003850602.1
• Coordinates: 24300..24551 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EE896_RS21370	19318..19764	-	447	WP_003850608.1	SgcJ/EcaC family oxidoreductase	-
EE896_RS21375	20450..20653	-	204	WP_078805279.1	hypothetical protein	-
EE896_RS21380	21397..23931	+	2535	WP_140915804.1	excinuclease ABC subunit UvrA	-
EE896_RS21385	24049..24303	-	255	WP_140034217.1	Txe/YoeB family addiction module toxin	Toxin
EE896_RS21390	24300..24551	-	252	WP_003850602.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
EE896_RS21395	24655..25968	-	1314	WP_140034218.1	CitMHS family transporter	-
EE896_RS21400	26308..27759	-	1452	WP_072040396.1	flagellin	-
EE896_RS21405	27965..28738	-	774	WP_003850595.1	(S)-acetoin forming diacetyl reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..138725	138725

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9940.32 Da
• Isoelectric Point: 8.8562

>T142392 WP_140034217.1 NZ_CP045722:c24303-24049 [Pantoea eucalypti]
VKLTWSAEAWEDYLYWQDTDKKTVRKINELLKDASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVTEEALLIASC
RYHY

Nucleotide

• Length: 255 bp

>T142392 NZ_CP060674:c3951846-3951478 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9323.52 Da
• Isoelectric Point: 4.5702

>AT142392 WP_003850602.1 NZ_CP045722:c24551-24300 [Pantoea eucalypti]
MRAISYSEARQNLSATMVQTVEDKAPVLITRQNGESCVLMSLDEYNSLEETAYLLRSPKNARRLMDAIESLQSGKGTDRD
IIE

Nucleotide

• Length: 252 bp

>AT142392 NZ_CP060674:c3952064-3951843 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A501RXB0