Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4055934..4056561 Replicon chromosome
Accession NZ_CP045712
Organism Escherichia coli strain FHI_NMBU_11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GHT02_RS19665 Protein ID WP_044706011.1
Coordinates 4056232..4056561 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GHT02_RS19660 Protein ID WP_086218972.1
Coordinates 4055934..4056242 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHT02_RS19615 4050986..4051441 - 456 WP_086218970.1 hypothetical protein -
GHT02_RS19620 4051432..4051968 - 537 WP_086218971.1 5'-deoxynucleotidase -
GHT02_RS19625 4052096..4052920 - 825 WP_000081284.1 DUF2303 family protein -
GHT02_RS19630 4052986..4053348 - 363 WP_000135680.1 hypothetical protein -
GHT02_RS19635 4053363..4053673 - 311 Protein_3832 hypothetical protein -
GHT02_RS19640 4054033..4054707 - 675 WP_000859463.1 LexA family transcriptional repressor -
GHT02_RS19645 4054798..4054998 + 201 WP_044705569.1 helix-turn-helix domain-containing protein -
GHT02_RS19650 4055042..4055593 + 552 WP_044705926.1 hypothetical protein -
GHT02_RS19655 4055739..4055912 + 174 Protein_3836 DUF4222 domain-containing protein -
GHT02_RS19660 4055934..4056242 - 309 WP_086218972.1 helix-turn-helix transcriptional regulator Antitoxin
GHT02_RS19665 4056232..4056561 - 330 WP_044706011.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHT02_RS19670 4056586..4057137 + 552 WP_086218973.1 ash family protein -
GHT02_RS19675 4057130..4057366 + 237 WP_077170670.1 hypothetical protein -
GHT02_RS19680 4057363..4058193 + 831 WP_086218974.1 helix-turn-helix domain-containing protein -
GHT02_RS19685 4058190..4058684 + 495 WP_001315196.1 PerC family transcriptional regulator -
GHT02_RS19690 4058684..4059337 + 654 WP_000066917.1 phage N-6-adenine-methyltransferase -
GHT02_RS19695 4059334..4059660 + 327 WP_000210169.1 LexA family transcriptional regulator -
GHT02_RS19700 4059657..4060046 + 390 WP_000767113.1 RusA family crossover junction endodeoxyribonuclease -
GHT02_RS19705 4060066..4060908 + 843 WP_001061422.1 KilA-N domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4022291..4094491 72200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-94)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12812.87 Da        Isoelectric Point: 9.6264

>T142345 WP_044706011.1 NZ_CP045712:c4056561-4056232 [Escherichia coli]
MNYTIEYYSEEVRLEVDQLPLSMRARYQHLVERMKVYGSNLGEPHTCAFGDGLFELRIKGSDGIARVFYCTLTGKRIIML
HSFIKKTQKTPPAERKKAETRMKEVKHDW

Download         Length: 330 bp

>T142345 NZ_CP060670:c515811-515593 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11171.87 Da        Isoelectric Point: 8.5840

>AT142345 WP_086218972.1 NZ_CP045712:c4056242-4055934 [Escherichia coli]
MTGKRTPPTMTHDEMAAKWMDDPAFKAEYDTIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGVSG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT142345 NZ_CP060670:c516213-515839 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References