Detailed information of TA system TA142323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 5390693..5391381
• Replicon: chromosome
• Accession: NZ_CP045702
• Organism: Streptomyces finlayi strain NBSH44

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: F0344_RS24805
• Protein ID: WP_185300876.1
• Coordinates: 5390693..5391076 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: F0344_RS24810
• Protein ID: WP_185300877.1
• Coordinates: 5391076..5391381 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0344_RS24785	5386093..5387511	+	1419	WP_185300874.1	trigger factor	-
F0344_RS24790	5387772..5388377	+	606	WP_185302875.1	ATP-dependent Clp protease proteolytic subunit	-
F0344_RS24795	5388469..5389137	+	669	WP_185302876.1	ATP-dependent Clp protease proteolytic subunit	-
F0344_RS24800	5389293..5390591	+	1299	WP_185300875.1	ATP-dependent Clp protease ATP-binding subunit ClpX	-
F0344_RS24805	5390693..5391076	+	384	WP_185300876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F0344_RS24810	5391076..5391381	+	306	WP_185300877.1	helix-turn-helix transcriptional regulator	Antitoxin
F0344_RS24815	5391883..5392857	-	975	WP_185300878.1	hypothetical protein	-
F0344_RS24820	5392994..5395615	+	2622	WP_185300879.1	valine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-115)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-89)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14397.26 Da
• Isoelectric Point: 5.6842

>T142323 WP_185300876.1 NZ_CP045702:5390693-5391076 [Streptomyces finlayi]
VDGPYELRFFADVLEWIQDLAKEDPDSHDHVIAALERLQECGPALRRPTVGAIDGSQFRNMRELRPRSGSSVSIRMLFVF
DPARRAVFLVAGNKASGRQWTAWYPKAIKQADANYIAHLEALKEEDD

Nucleotide

• Length: 384 bp

>T142323 NZ_CP060666:4680742-4681017 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10701.37 Da
• Isoelectric Point: 9.8629

>AT142323 WP_185300877.1 NZ_CP045702:5391076-5391381 [Streptomyces finlayi]
MKLGSMADLTADITPEKRARVDAIKSEMVDAERGHELASLRKAQGMTQVQAAKAMGVTQGRISQIERGGVRLDTSTMSAY
LQAIGGELTILATVGNVSVKL

Nucleotide

• Length: 306 bp

>AT142323 NZ_CP060666:4680479-4680739 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA