Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2605002..2605528 Replicon chromosome
Accession NZ_CP045702
Organism Streptomyces finlayi strain NBSH44

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F0344_RS11705 Protein ID WP_185298719.1
Coordinates 2605259..2605528 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F0344_RS11700 Protein ID WP_138358631.1
Coordinates 2605002..2605262 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0344_RS11690 2600073..2601467 - 1395 WP_185298717.1 SWIM zinc finger family protein -
F0344_RS11695 2601464..2604679 - 3216 WP_185298718.1 DEAD/DEAH box helicase -
F0344_RS11700 2605002..2605262 + 261 WP_138358631.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F0344_RS11705 2605259..2605528 + 270 WP_185298719.1 Txe/YoeB family addiction module toxin Toxin
F0344_RS11710 2606177..2606341 + 165 Protein_2322 hypothetical protein -
F0344_RS11715 2606653..2606904 + 252 WP_185298720.1 hypothetical protein -
F0344_RS11720 2606904..2607296 + 393 WP_185298721.1 DNA-binding protein -
F0344_RS11725 2607609..2607815 + 207 Protein_2325 site-specific integrase -
F0344_RS11730 2607924..2609012 - 1089 WP_185298722.1 redox-regulated ATPase YchF -
F0344_RS11735 2609218..2609820 + 603 WP_185298723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10408.84 Da        Isoelectric Point: 10.5158

>T142320 WP_185298719.1 NZ_CP045702:2605259-2605528 [Streptomyces finlayi]
VKVMFSTRAWEQYAQWAMTDRRGLKRINVLIADIQRNPDDGNGTGKPEMLKGALKDWRSRRITEEHRLVYRASGDVLEIA
RVYGHHTDR

Download         Length: 270 bp

>T142320 NZ_CP060666:4132296-4132607 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9456.61 Da        Isoelectric Point: 4.2577

>AT142320 WP_138358631.1 NZ_CP045702:2605002-2605262 [Streptomyces finlayi]
MTITGTEARRDFFPLLKKVNDDHAPVRIASKQGNAVLMAESDYEAWTETMYLLGNARTAAELMESVAELDAGRGTVRDLI
DPEAAE

Download         Length: 261 bp

>AT142320 NZ_CP060666:4132604-4133050 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References