Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 870857..871593 Replicon chromosome
Accession NZ_CP045700
Organism Vibrio sp. SM1977

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GFB47_RS15845 Protein ID WP_153448933.1
Coordinates 870857..871168 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GFB47_RS15850 Protein ID WP_153448934.1
Coordinates 871165..871593 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFB47_RS15830 867298..868653 + 1356 WP_153448930.1 N-succinylarginine dihydrolase -
GFB47_RS15835 868737..869870 + 1134 WP_153448931.1 succinylglutamate desuccinylase -
GFB47_RS15840 869867..870637 - 771 WP_153448932.1 hypothetical protein -
GFB47_RS15845 870857..871168 + 312 WP_153448933.1 type II toxin-antitoxin system HigB family toxin Toxin
GFB47_RS15850 871165..871593 + 429 WP_153448934.1 helix-turn-helix domain-containing protein Antitoxin
GFB47_RS15855 871689..873059 - 1371 WP_153449043.1 L-serine ammonia-lyase -
GFB47_RS15860 873273..874325 + 1053 WP_153448935.1 ABC transporter substrate-binding protein -
GFB47_RS15865 874339..875235 + 897 WP_153448936.1 alkaline phosphatase family protein -
GFB47_RS15870 875339..876178 + 840 WP_178306548.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(9-140)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12185.01 Da        Isoelectric Point: 9.7430

>T142313 WP_153448933.1 NZ_CP045700:870857-871168 [Vibrio sp. SM1977]
MHVISRKPFSDASRKYPNDATAIDALYKSLKNNNFSNPLEMKNVYPSLDNFKYKDKWYVLDIGGNNLRLITFIEFRDHRM
FVKCIVPHAEYDKLCSRYAKESK

Download         Length: 312 bp

>T142313 NZ_CP060666:3053971-3054189 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 16127.38 Da        Isoelectric Point: 4.3412

>AT142313 WP_153448934.1 NZ_CP045700:871165-871593 [Vibrio sp. SM1977]
MKNFNQLKSTALELFTMASFVGHISNDEEYTEALALMEELIEEYDLYKPLIEVLAVSIERWEDNADEFAEFNRRIEGLDN
GVATLRVLMDQYQLKADDLKDVIGGKSLVSMILNGSRKLTKEHIQAISSKYNISPALFFASV

Download         Length: 429 bp

>AT142313 NZ_CP060666:3053569-3053943 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References