Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 793392..793966 Replicon chromosome
Accession NZ_CP045699
Organism Vibrio sp. SM1977

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GFB47_RS03625 Protein ID WP_153446620.1
Coordinates 793392..793670 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GFB47_RS03630 Protein ID WP_153446622.1
Coordinates 793670..793966 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFB47_RS03610 788635..790005 + 1371 WP_153446615.1 acetyl-CoA C-acyltransferase FadI -
GFB47_RS03615 790005..792143 + 2139 WP_153446617.1 fatty acid oxidation complex subunit alpha FadJ -
GFB47_RS03620 792327..793265 + 939 WP_153446618.1 diguanylate cyclase -
GFB47_RS03625 793392..793670 + 279 WP_153446620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GFB47_RS03630 793670..793966 + 297 WP_153446622.1 HigA family addiction module antidote protein Antitoxin
GFB47_RS03635 794057..796867 - 2811 WP_153446623.1 insulinase family protein -
GFB47_RS03640 797306..797764 + 459 WP_153446625.1 phosphohistidine phosphatase SixA -
GFB47_RS03645 797856..798386 - 531 WP_153446627.1 endonuclease SmrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10860.53 Da        Isoelectric Point: 9.9958

>T142310 WP_153446620.1 NZ_CP045699:793392-793670 [Vibrio sp. SM1977]
MIKNFIHKGLRKFYISGGTAGIQKKHEKKLRLILANLDQAEVPDDMDLPGLFMHQLKGDRKDIWSVRVNGNWRITYRFTG
RDVEIVNYEDYH

Download         Length: 279 bp

>T142310 NZ_CP060666:c630172-629645 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11048.76 Da        Isoelectric Point: 8.6923

>AT142310 WP_153446622.1 NZ_CP045699:793670-793966 [Vibrio sp. SM1977]
MAMFNPAHPGEILKELVIDSLELTITDVAKHLDVSRKTLSKVLNAKGSVTPEMAVRLELAFGKPSADHWLRLQNAHDLWK
TRQQQSSLHVSPYNFQMA

Download         Length: 297 bp

>AT142310 NZ_CP060666:c630459-630169 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References