Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 353056..353702 Replicon chromosome
Accession NZ_CP045694
Organism Klebsiella pneumoniae strain TK421

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GHA50_RS03255 Protein ID WP_023317328.1
Coordinates 353056..353403 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GHA50_RS03260 Protein ID WP_032412314.1
Coordinates 353403..353702 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHA50_RS03245 348982..350415 + 1434 WP_002920564.1 glycogen synthase GlgA -
GHA50_RS03250 350433..352880 + 2448 WP_002920561.1 glycogen phosphorylase -
GHA50_RS03255 353056..353403 + 348 WP_023317328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHA50_RS03260 353403..353702 + 300 WP_032412314.1 XRE family transcriptional regulator Antitoxin
GHA50_RS03265 353765..355273 - 1509 WP_032412313.1 glycerol-3-phosphate dehydrogenase -
GHA50_RS03270 355478..355807 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
GHA50_RS03275 355858..356688 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
GHA50_RS03280 356738..357496 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.60 Da        Isoelectric Point: 6.2327

>T142288 WP_023317328.1 NZ_CP045694:353056-353403 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
ILCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T142288 NZ_CP060593:c60350-60054 [Rouxiella badensis]
ATGGAAAAGAAAACGCCCCATACGCGCCTGCATCTTGTTCAAGCCTTAGTTGCTGAGGGCAAGGTTAGGGCTACCAATAC
GGCCATGAACGGCGCTGATGAATTGGGACTGACCTTCGACGGCATGTGTGATGCAATCAAAGGATTGAAAATGAGTGATT
TTTTTAAAAGTATGACGACTTACAACGATCATACCGTGTGGCAGGATGTTTACAGACCTACGCTGGCGTGTGGGGTTGTT
TACTTAAAGCTTACCGTCAGCAACGGCGTTTTGATCGTATCATTCAAGGAGAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10828.64 Da        Isoelectric Point: 10.1464

>AT142288 WP_032412314.1 NZ_CP045694:353403-353702 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGIKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT142288 NZ_CP060593:c60052-59657 [Rouxiella badensis]
ATGAAATGTTCAGTGTGTGGCGGTGCAGAACTGGCGTTCGGGACTAAAAAAGTGCCTTATTCCTTCCGTGGTCACAAGAC
CCAGATCGACGCCGAGGGTGAACATTGCCCCGCCTGCGGTGAGGTGAATATGGACCGCGATCAGGCTAACGCTTATCAGG
CAAAACTGAAGGCGTTCAAAGCGCAAATCATCGCAGTGACCGTTGAGCCTGAGTTTATTGTGAGCGTACGGAAAAAATTG
GCGCTGACCCAGAAAGAAGCAAGTGAGATATTTGGGGGCGGTGTGAATGCCTTCTCGCGGTATGAAAAGGGTGTAGCTCA
GCCGCACCCCTCCACGATAAAATTGCTTCGTGTCTTGGATCATCACCCCGAATTATTGAATGAAATACGCGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References