Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 45439..46113 Replicon plasmid pWSD411_3
Accession NZ_CP045676
Organism Klebsiella pneumoniae strain WSD411

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LMS5
Locus tag F8D37_RS26475 Protein ID WP_032720638.1
Coordinates 45439..45762 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F8D37_RS26480 Protein ID WP_032720637.1
Coordinates 45811..46113 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8D37_RS26455 40461..41864 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
F8D37_RS26460 41976..43508 + 1533 WP_023288255.1 IS3-like element ISKpn38 family transposase -
F8D37_RS26465 43780..44382 + 603 Protein_47 transposase -
F8D37_RS26470 44709..45261 + 553 Protein_48 DUF4113 domain-containing protein -
F8D37_RS26475 45439..45762 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8D37_RS26480 45811..46113 + 303 WP_032720637.1 helix-turn-helix domain-containing protein Antitoxin
F8D37_RS26485 46156..46323 - 168 WP_153591440.1 hypothetical protein -
F8D37_RS26490 46511..46690 - 180 WP_032720701.1 hypothetical protein -
F8D37_RS26495 46714..47097 - 384 WP_032720636.1 hypothetical protein -
F8D37_RS26500 47202..47774 - 573 WP_032720635.1 GNAT family N-acetyltransferase -
F8D37_RS26505 47776..48564 - 789 WP_032720700.1 TSUP family transporter -
F8D37_RS26510 48600..49520 - 921 WP_050548604.1 TauD/TfdA family dioxygenase -
F8D37_RS26515 49823..50317 - 495 WP_044266755.1 hypothetical protein -
F8D37_RS26520 50348..50920 - 573 WP_044266753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146858 146858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13860.82 Da        Isoelectric Point: 12.8294

>T142279 WP_032720638.1 NZ_CP045676:45439-45762 [Klebsiella pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 324 bp

>T142279 NZ_CP060584:c1006735-1006640 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 12963.60 Da        Isoelectric Point: 12.8000

>AT142279 WP_032720637.1 NZ_CP045676:45811-46113 [Klebsiella pneumoniae]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Download         Length: 303 bp

>AT142279 NZ_CP060584:1006553-1006612 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LMS5

Antitoxin

Source ID Structure

References