Detailed information of TA system TA142276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1887461..1887963
• Replicon: chromosome
• Accession: NZ_CP045670
• Organism: Treponema pedis strain T3552B

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S6A4C3
• Locus tag: DYQ05_RS08700
• Protein ID: WP_020965624.1
• Coordinates: 1887703..1887963 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DYQ05_RS08695
• Protein ID: WP_024465572.1
• Coordinates: 1887461..1887703 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYQ05_RS08680	1883552..1885003	+	1452	WP_206183270.1	aminomethyl-transferring glycine dehydrogenase subunit GcvPB	-
DYQ05_RS08685	1885215..1885451	+	237	WP_020965621.1	exodeoxyribonuclease VII small subunit	-
DYQ05_RS08690	1885466..1887367	+	1902	WP_206183271.1	DNA mismatch repair endonuclease MutL	-
DYQ05_RS08695	1887461..1887703	+	243	WP_024465572.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DYQ05_RS08700	1887703..1887963	+	261	WP_020965624.1	Txe/YoeB family addiction module toxin	Toxin
DYQ05_RS08705	1887954..1888367	-	414	WP_020965625.1	hypothetical protein	-
DYQ05_RS08710	1888371..1889756	-	1386	WP_206183272.1	hypothetical protein	-
DYQ05_RS08715	1889873..1890700	-	828	WP_144299225.1	hypothetical protein	-
DYQ05_RS08720	1890760..1891226	-	467	Protein_1707	SsrA-binding protein SmpB	-
DYQ05_RS08725	1891429..1892370	-	942	WP_206183273.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10444.24 Da
• Isoelectric Point: 10.4076

>T142276 WP_020965624.1 NZ_CP045670:1887703-1887963 [Treponema pedis]
MWIIKYAKEAVRDSKKIERSNLKQTVINLIEILKINPFQNPPPYEKLLGDLTGKYSRRINIQHRLVYEVFENKNTVRILR
MWTHYE

Nucleotide

• Length: 261 bp

>T142276 NZ_CP060584:776631-776993 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9154.40 Da
• Isoelectric Point: 4.7571

>AT142276 WP_024465572.1 NZ_CP045670:1887461-1887703 [Treponema pedis]
MMVMTATQARSNLHTLIDKTKNFHEPIIISGKRHNAVLISEEDWNSIQETLYLYSVPGLRESIIEASKEPLENSIEDIGW

Nucleotide

• Length: 243 bp

>AT142276 NZ_CP060584:776464-776634 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: S6A4C3