Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 686333..687027 Replicon chromosome
Accession NZ_CP045640
Organism Yersinia pestis strain S19960127

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag S96127_RS04130 Protein ID WP_002214787.1
Coordinates 686333..686629 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag S96127_RS04135 Protein ID WP_002209924.1
Coordinates 686629..687027 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S96127_RS04100 681455..682972 + 1518 WP_002209930.1 lysine--tRNA ligase -
S96127_RS04110 683405..684619 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
S96127_RS04115 684701..684886 - 186 WP_002209928.1 hypothetical protein -
S96127_RS04120 685484..685744 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
S96127_RS04125 685807..686169 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
S96127_RS04130 686333..686629 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
S96127_RS04135 686629..687027 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
S96127_RS04140 687427..689718 - 2292 WP_002209923.1 toprim domain-containing protein -
S96127_RS04145 690018..690344 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
S96127_RS04150 690337..690489 + 153 WP_002209921.1 hypothetical protein -
S96127_RS04155 690503..690703 - 201 WP_002209920.1 AlpA family transcriptional regulator -
S96127_RS04160 690885..691217 - 333 WP_002214791.1 hypothetical protein -
S96127_RS04165 691223..691459 - 237 WP_002214792.1 hypothetical protein -
S96127_RS04170 691472..691837 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T142220 WP_002214787.1 NZ_CP045640:686333-686629 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T142220 NZ_CP060463:16327-16653 [Xanthomonas citri pv. citri]
ATGATGCGAGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTCATCCAGGCCAA
CCAGTTTGACGAACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTTGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGCCTGCTGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
ATAGGTCGGGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT142220 WP_002209924.1 NZ_CP045640:686629-687027 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT142220 NZ_CP060463:16113-16340 [Xanthomonas citri pv. citri]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGTGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGAGGACA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGATGATGCGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References