Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 30350..30858 Replicon plasmid pS96127
Accession NZ_CP045639
Organism Yersinia pestis strain S19960127

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K1H0I1
Locus tag S96127_RS01220 Protein ID WP_016257350.1
Coordinates 30598..30858 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1E7YXI3
Locus tag S96127_RS01215 Protein ID WP_016257351.1
Coordinates 30350..30601 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S96127_RS01190 26902..27240 - 339 WP_016257047.1 hypothetical protein -
S96127_RS01195 27237..27455 - 219 WP_016257048.1 ANR family transcriptional regulator -
S96127_RS01200 27677..28624 - 948 WP_016257049.1 replication initiation protein -
S96127_RS01205 29071..29898 + 828 WP_134809573.1 DUF4236 domain-containing protein -
S96127_RS01210 29927..30292 + 366 WP_016257352.1 hypothetical protein -
S96127_RS01215 30350..30601 + 252 WP_016257351.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
S96127_RS01220 30598..30858 + 261 WP_016257350.1 Txe/YoeB family addiction module toxin Toxin
S96127_RS01225 30861..31421 + 561 WP_016257349.1 3'-5' exoribonuclease -
S96127_RS01230 31400..31615 - 216 WP_071588212.1 WGR domain-containing protein -
S96127_RS01235 31748..31975 - 228 WP_016257348.1 hypothetical protein -
S96127_RS01240 31972..32595 - 624 WP_016257347.1 ParA family protein -
S96127_RS01245 33215..33517 + 303 WP_016257346.1 phage holin family protein -
S96127_RS01250 33519..33944 + 426 WP_025476582.1 lysozyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33991 33991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10232.70 Da        Isoelectric Point: 9.5040

>T142218 WP_016257350.1 NZ_CP045639:30598-30858 [Yersinia pestis]
VKLVFSDQSWADYLHWQQTDKSMLKRVNLLIKDIQREPFSGMGKPEPLKHHLSGFWSRRIDSEHRLVYRVTDDSLLIASC
RYHYTG

Download         Length: 261 bp

>T142218 NZ_CP060461:c6873-6541 [Xanthomonas citri pv. citri]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9495.74 Da        Isoelectric Point: 4.4488

>AT142218 WP_016257351.1 NZ_CP045639:30350-30601 [Yersinia pestis]
MKTMNYSEARQNFASVMNETIDDRAPILITRQKGMPCVLMSLEEYDSLEETAYLLRSPVNARHLMDSIEQLNNGKGTERD
LAE

Download         Length: 252 bp

>AT142218 NZ_CP060461:c7130-6873 [Xanthomonas citri pv. citri]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1H0I1

Antitoxin

Source ID Structure
AlphaFold DB A0A1E7YXI3

References