Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2802269..2802791 Replicon chromosome
Accession NZ_CP045586
Organism Lacticaseibacillus rhamnosus strain TK-F8B

Toxin (Protein)


Gene name yoeB Uniprot ID C2JUK2
Locus tag GFB59_RS13170 Protein ID WP_005687756.1
Coordinates 2802531..2802791 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C2JUK3
Locus tag GFB59_RS13165 Protein ID WP_005687754.1
Coordinates 2802269..2802538 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFB59_RS13145 2797856..2798425 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
GFB59_RS13150 2798438..2798947 - 510 WP_005687749.1 transcriptional regulator GutM -
GFB59_RS13155 2798948..2800816 - 1869 WP_005687750.1 HTH domain-containing protein -
GFB59_RS13160 2800843..2801643 - 801 WP_005687752.1 SDR family oxidoreductase -
GFB59_RS13165 2802269..2802538 + 270 WP_005687754.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GFB59_RS13170 2802531..2802791 + 261 WP_005687756.1 Txe/YoeB family addiction module toxin Toxin
GFB59_RS13175 2803002..2803730 - 729 WP_005687757.1 L-ribulose-5-phosphate 4-epimerase -
GFB59_RS13180 2803927..2804748 + 822 WP_005687759.1 Cof-type HAD-IIB family hydrolase -
GFB59_RS13185 2804815..2805702 - 888 WP_005687761.1 L-ribulose-5-phosphate 3-epimerase -
GFB59_RS13190 2805886..2806665 - 780 WP_005690765.1 DeoR/GlpR family DNA-binding transcription regulator -
GFB59_RS13195 2806733..2807374 - 642 WP_005687764.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10485.91 Da        Isoelectric Point: 9.6577

>T142156 WP_005687756.1 NZ_CP045586:2802531-2802791 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS

Download         Length: 261 bp

>T142156 NZ_CP060421:843282-843692 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCTCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT142156 WP_005687754.1 NZ_CP045586:2802269-2802538 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp

>AT142156 NZ_CP060421:843035-843301 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249N526

Antitoxin

Source ID Structure
AlphaFold DB A0A249N594

References