Detailed information of TA system TA142150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3079559..3080259
• Replicon: chromosome
• Accession: NZ_CP045571
• Organism: Acidithiobacillus thiooxidans ATCC 19377

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: GCD22_RS16240
• Protein ID: WP_031571604.1
• Coordinates: 3079963..3080259 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A543Q601
• Locus tag: GCD22_RS16235
• Protein ID: WP_010639323.1
• Coordinates: 3079559..3079960 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCD22_RS16210	3075061..3076830	+	1770	WP_031568728.1	CpaF family protein	-
GCD22_RS16215	3076820..3077719	+	900	WP_010637573.1	pilus assembly protein	-
GCD22_RS16220	3078120..3078593	+	474	Protein_3161	IS110 family transposase	-
GCD22_RS18260	3078836..3079081	-	246	WP_202806216.1	transposase	-
GCD22_RS18265	3079078..3079347	-	270	WP_142087859.1	transposase	-
GCD22_RS16230	3079362..3079543	-	182	Protein_3164	winged helix-turn-helix domain-containing protein	-
GCD22_RS16235	3079559..3079960	-	402	WP_010639323.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
GCD22_RS16240	3079963..3080259	-	297	WP_031571604.1	type II toxin-antitoxin system MqsR family toxin	Toxin
GCD22_RS16245	3080396..3081334	-	939	WP_031571606.1	uracil-DNA glycosylase	-
GCD22_RS16250	3081498..3081848	+	351	WP_031571608.1	DUF4870 domain-containing protein	-
GCD22_RS16255	3081942..3083801	+	1860	WP_031571610.1	ATP-binding cassette domain-containing protein	-
GCD22_RS16260	3084017..3084292	-	276	WP_031571614.1	hypothetical protein	-
GCD22_RS16265	3084303..3084614	-	312	WP_031571616.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3078054..3078593	539

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10964.73 Da
• Isoelectric Point: 7.3565

>T142150 WP_031571604.1 NZ_CP045571:c3080259-3079963 [Acidithiobacillus thiooxidans ATCC 19377]
MEKQVPHCKLSVVKALAKTGRVRTTHAARTGANELGLVFSDMLDVLMTLTPTDFYKSMTTHADHTVWQDVYRPGTQVGDV
YLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T142150 NZ_CP060415:c2269-1991 [Neisseria musculi]
GTGCTGCCCGTTGAGTGGAAACTGGCGGCTAGGCTGGATTTGATTGAAATCATCGACTACATCGCGCAGGAAAATCCGCA
GGCTGCTGAAAAAATGAAGCGTCTGCTTGATGATACTGCCGAACGGCTCGGCGAAATGCCTTACATCAACCGTCGCGGCC
GAGTAGCAGGTACACGGGAAAAGATAGCGCATAGAAACTACATCATCGTGTACCGCATAACCAGCGATAAAGTTGAAATT
CTAAACATCGTGCATAGCCGTAAAAATTATCCGGACTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14628.82 Da
• Isoelectric Point: 6.4556

>AT142150 WP_010639323.1 NZ_CP045571:c3079960-3079559 [Acidithiobacillus thiooxidans ATCC 19377]
MKCPVCGAAELIHDTRDLPYTYKGETTVIATVTGDFCPACAESVLDAAESNRVMREMRAFSKQVNAAIVDPGFIADVRKK
LDLDQREAAEIFGGGINAFSRYENGKTKPPLALVKLFKLLDRHPDLLNEVRTA

Nucleotide

• Length: 402 bp

>AT142150 NZ_CP060415:c2450-2256 [Neisseria musculi]
ATGAATACCGCCTTTTTAGACCCTCTGATTTACGAATTTGATACTGTCGAAGAAGCAGAAAGCTATGATGCTTGGTTTCG
TGCCAAAGTTGAAAAATCCATCGCTGACCCTACACCGTCAATGCCGCATGATGAAGCTATGGCTTTCGTAGATGCCGAAC
TGGAACGCAGGAGGGCCGCCCGTGCTGCCCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A543Q601