Detailed information of TA system TA142093

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 18655..18919
• Replicon: plasmid p6607-69
• Accession: NZ_CP045527
• Organism: Shigella sonnei strain 6607.69

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: GE169_RS24700
• Protein ID: WP_001387489.1
• Coordinates: 18655..18807 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	18859..18919 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE169_RS24670 (14569)	14569..16089	+	1521	Protein_16	DotA/TraY family protein	-
GE169_RS24675 (16160)	16160..16822	+	663	WP_012783935.1	plasmid IncI1-type surface exclusion protein ExcA	-
GE169_RS24680 (16894)	16894..17103	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
GE169_RS24685 (17495)	17495..17671	+	177	WP_001054900.1	hypothetical protein	-
GE169_RS25170 (17736)	17736..17831	-	96	WP_000609148.1	DinQ-like type I toxin DqlB	-
GE169_RS24695 (18332)	18332..18583	+	252	WP_001291964.1	hypothetical protein	-
GE169_RS24700 (18655)	18655..18807	-	153	WP_001387489.1	Hok/Gef family protein	Toxin
- (18859)	18859..18919	+	61	NuclAT_0	-	Antitoxin
- (18859)	18859..18919	+	61	NuclAT_0	-	Antitoxin
- (18859)	18859..18919	+	61	NuclAT_0	-	Antitoxin
- (18859)	18859..18919	+	61	NuclAT_0	-	Antitoxin
GE169_RS24705 (19434)	19434..20213	+	780	WP_275450201.1	protein FinQ	-
- (20283)	20283..20340	+	58	NuclAT_1	-	-
- (20283)	20283..20340	+	58	NuclAT_1	-	-
- (20283)	20283..20340	+	58	NuclAT_1	-	-
- (20283)	20283..20340	+	58	NuclAT_1	-	-
GE169_RS24710 (20520)	20520..21728	+	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
GE169_RS24715 (21747)	21747..22817	+	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-15	-	1..89848	89848

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T142093 WP_001387489.1 NZ_CP045527:c18807-18655 [Shigella sonnei]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T142093 NZ_CP060396:c3227598-3227212 [Synechococcus sp. CBW1006]
ATGCTGGACACCAACGCCATGAGCGCCTTTCTCCAACGACGCTCGCCACGGCTGGATAGCTGGGTGCGTGAGCAACGTTG
TTGCCTGTCCGCCATTGTTGTGGCCGAGATCCGCTACGGGCTGGAGAAGCTGCCGCCCACTTCGCGGATGCAGACGCGGT
TACAGGAGCTGGCGGAGGCCACCCTCGAGACCCTGGAGATCCTGCCCTGGTCGGAAGCGTGCACGAGGATCTACGGCCGG
CTGCGCGCCGATCTCGAACGCCATGGCAAGCCTCTGGCGGTGATGGACCTCCTGATCGCCAGCCATGCCCTCAGCGAAGG
CTGCGCCCTGGTGACGGCGGATCGGGCCTTCGCCAAGGTGGCCGAACTCCACCTGGAGGCCTGGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT142093 NZ_CP045527:18859-18919 [Shigella sonnei]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin