Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2181919..2182646 Replicon chromosome
Accession NZ_CP045526
Organism Shigella sonnei strain 6607.69

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag GE169_RS11430 Protein ID WP_000550189.1
Coordinates 2181919..2182233 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GE169_RS11435 Protein ID WP_000560263.1
Coordinates 2182230..2182646 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE169_RS11410 (2178084) 2178084..2179070 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
GE169_RS11415 (2179149) 2179149..2179832 - 684 WP_001183060.1 vancomycin high temperature exclusion protein -
GE169_RS11420 (2179909) 2179909..2180412 - 504 WP_001305117.1 M48 family metallopeptidase -
GE169_RS11425 (2180497) 2180497..2181633 + 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
GE169_RS11430 (2181919) 2181919..2182233 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
GE169_RS11435 (2182230) 2182230..2182646 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
GE169_RS11440 (2182691) 2182691..2184709 - 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
GE169_RS11445 (2184935) 2184935..2187286 - 2352 WP_000695471.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T142089 WP_000550189.1 NZ_CP045526:2181919-2182233 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T142089 NZ_CP060396:c2736662-2736318 [Synechococcus sp. CBW1006]
GTGAACACCTTCGAGACCTACACGGTGGTCCGGGTGCCGTTTCCGTTCACCGAGCGGCAGGCCCAGAAGCAACGGCCAGC
GGTGGTGCTCTCACGGCCCAGCTTTCAGCGAGGCTGTGGCCATCTGCTGCTGGCGATGATCACATCGGCGCGGCAATCCT
CGTGGCCCCTCGATTGGCCCCTTGACGATCTCCAGGCTGCAGGCCTGCCTCAACCCTGCCTGGTTCGCTTCAAGTTGTTC
ACCCTTGATGAGCGACTGGTGTTGGGTGAGCTGGGCGTGCTGGGCGCCGCCGATCGCGCCGGCGTGTCGGCCCATTTGGG
CCATCTACTGCCCACCGGGACCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT142089 WP_000560263.1 NZ_CP045526:2182230-2182646 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT142089 NZ_CP060396:c2736883-2736659 [Synechococcus sp. CBW1006]
ATGGACGTCGCCACACTCACTGCCAAGGGGCAGGTCACAGTGCCGAAGGCTGTGCGTGAGGCCCTGGGATTGCGGCGGGG
CGATCAGCTCAGTTGGGAGCTGGAGGATGGCTCGGTGCGGGTGCGGGCGGTGACGCCATTGGATCTGGCCTATCTCCACG
GGCTGGAGCGGGGCCTGAGCGAATGGAGCAGCCCGGCGGACGAGGAAGCGTTCCGCGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References