Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1045204..1045706 | Replicon | chromosome |
| Accession | NZ_CP045526 | ||
| Organism | Shigella sonnei strain 6607.69 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | GE169_RS05680 | Protein ID | WP_000767829.1 |
| Coordinates | 1045204..1045458 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | GE169_RS05685 | Protein ID | WP_001259255.1 |
| Coordinates | 1045455..1045706 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE169_RS05650 (1040219) | 1040219..1040446 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| GE169_RS05655 (1040460) | 1040460..1041518 | - | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| GE169_RS05660 (1041697) | 1041697..1043055 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| GE169_RS05665 (1043045) | 1043045..1043107 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| GE169_RS05670 (1043322) | 1043322..1044251 | - | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| GE169_RS05675 (1044297) | 1044297..1045121 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| GE169_RS05680 (1045204) | 1045204..1045458 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| GE169_RS05685 (1045455) | 1045455..1045706 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| GE169_RS05690 (1045989) | 1045989..1046039 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| GE169_RS05695 (1046185) | 1046185..1047084 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| GE169_RS05700 (1047090) | 1047090..1048394 | + | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| GE169_RS05705 (1048391) | 1048391..1049461 | + | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
| GE169_RS05710 (1049461) | 1049461..1050528 | + | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T142085 WP_000767829.1 NZ_CP045526:c1045458-1045204 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T142085 NZ_CP060396:886601-886858 [Synechococcus sp. CBW1006]
GTGCTGGGTGTAGTCGTGGTGCGAGCGAAGCTGGTCAAAATCGGCAACTCGAGAGGGATCCGCCTCGCCAAGCCACTGCT
TGAGGTTGCGGGGCTCGCTGACGAAGTCGAGATCGAAGCGGCTCCAGGGGTTCTGACCATCAGGCCATCCGCTCATCCGA
GGGCTGGCTGGGCAGAGGCGGCATCGTCTTTGGAGCCAGAGGGACTTCTGGATGAAATGAGCGCCACCCAGTTTGATGAC
GAAGAGTGGTCATGGTGA
GTGCTGGGTGTAGTCGTGGTGCGAGCGAAGCTGGTCAAAATCGGCAACTCGAGAGGGATCCGCCTCGCCAAGCCACTGCT
TGAGGTTGCGGGGCTCGCTGACGAAGTCGAGATCGAAGCGGCTCCAGGGGTTCTGACCATCAGGCCATCCGCTCATCCGA
GGGCTGGCTGGGCAGAGGCGGCATCGTCTTTGGAGCCAGAGGGACTTCTGGATGAAATGAGCGCCACCCAGTTTGATGAC
GAAGAGTGGTCATGGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT142085 WP_001259255.1 NZ_CP045526:c1045706-1045455 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT142085 NZ_CP060396:886852-887187 [Synechococcus sp. CBW1006]
ATGGTGACTGAAGAACACGTCTCAAGAGGCAATATCTTCCTTGTCGCGTTGAATCCCACGCGAGGATCTGAAATCAGGAA
GACGAGGCCTTGTGCCGTAGTGTCGCCGGACGAGCTTAATGCTCACCTTCGCACTTTCATTGTTGCGCCGCTCACAACTG
GCGGCCATCCATACCCATTTCGTGTGCGTTGCAGGTTTGATGGCAAGGACGGCCATGTTGTGGCTGATCAGCTGAGAGCT
GTAGACAGAGACCGTCTAGTCAAGCGGTTGGGGAGTCTGTCGGAGACTACGCTGAATGAACTGCTGAGTGTTCTTCAGGC
GATGTTCGCTGTGTAG
ATGGTGACTGAAGAACACGTCTCAAGAGGCAATATCTTCCTTGTCGCGTTGAATCCCACGCGAGGATCTGAAATCAGGAA
GACGAGGCCTTGTGCCGTAGTGTCGCCGGACGAGCTTAATGCTCACCTTCGCACTTTCATTGTTGCGCCGCTCACAACTG
GCGGCCATCCATACCCATTTCGTGTGCGTTGCAGGTTTGATGGCAAGGACGGCCATGTTGTGGCTGATCAGCTGAGAGCT
GTAGACAGAGACCGTCTAGTCAAGCGGTTGGGGAGTCTGTCGGAGACTACGCTGAATGAACTGCTGAGTGTTCTTCAGGC
GATGTTCGCTGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|