142069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4228165..4228892 Replicon chromosome
Accession NZ_CP045524
Organism Shigella sonnei strain 6904.27

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag GE168_RS21255 Protein ID WP_000550189.1
Coordinates 4228578..4228892 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GE168_RS21250 Protein ID WP_000560263.1
Coordinates 4228165..4228581 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE168_RS21240 (4223525) 4223525..4225876 + 2352 WP_000695471.1 alpha-glucosidase -
GE168_RS21245 (4226102) 4226102..4228120 + 2019 WP_000121451.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
GE168_RS21250 (4228165) 4228165..4228581 - 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
GE168_RS21255 (4228578) 4228578..4228892 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
GE168_RS21260 (4229177) 4229177..4230313 - 1137 WP_000018685.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
GE168_RS21265 (4230398) 4230398..4230901 + 504 WP_001305117.1 M48 family metallopeptidase -
GE168_RS21270 (4230978) 4230978..4231661 + 684 WP_001183060.1 vancomycin high temperature exclusion protein -
GE168_RS21275 (4231740) 4231740..4232726 + 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T142069 WP_000550189.1 NZ_CP045524:c4228892-4228578 [Shigella sonnei]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T142069 NZ_CP060395:c1018161-1017757 [Synechococcus sp. CBW1108]
ATGGTGATTGACACCTCTGCCGTGCTGGCAATCCTCCAGGACGAGCCCGAGGGCAGTGCTTTCAACACCGTGATTGCCGC
CGCCGAGAGTTGCATGCTCTCGGCGGCGTCCCTCATAGAGCTATCCATCGTGCTGGAAGCTCGCTTAGGCCCTGACGGCC
AGCGCGATCTGGATCTGTTCCTCAGCACGGCTCAGATCAACATGGTGGCTGTTGATCGCGATCAGGCCGAGCTCCCCCGC
AGGGCCTTCGGCCGCTACGGCAAAGGCCGGCATCGTGCTGGCTTGAATTTCGGCGATTGCTTCTCCTACGCCCTGGCCAA
GGGGGTTGGCGTTCCTTTGCTGTTTAAGGGCAACGATTTCAGTCATACCGATCTGGAGTCGGCCTGGAACCCCGCTGCCA
GCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT142069 WP_000560263.1 NZ_CP045524:c4228581-4228165 [Shigella sonnei]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT142069 NZ_CP060395:c1018430-1018161 [Synechococcus sp. CBW1108]
ATGGCGCTGAACATTCGCAATCCAGAGGCAAACAGGCTTGCAGCGGAGGTGGCTGCTCTCGCTGGAGAAAGCAATACCGT
CGTCGTGATCCTGGCCCGCGAGGAACGTCTGCAGCGGCTACGCCGCCAGCAGACGGCCCGTCCTGATGCCCAGGAGCTCC
TCGCCAGTCGTCTTGATCAGATCGCCCTGAGCTGTGCTGCCAGGCCGAGGCGCGACCAGCGCACGGCAGAGCAGATTCTC
GGCTACGACGCCGGTGGCCTGCCCTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References