Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 538045..538547 | Replicon | chromosome |
| Accession | NZ_CP045524 | ||
| Organism | Shigella sonnei strain 6904.27 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | GE168_RS02615 | Protein ID | WP_000767829.1 |
| Coordinates | 538293..538547 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | GE168_RS02610 | Protein ID | WP_001259255.1 |
| Coordinates | 538045..538296 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE168_RS02585 (533223) | 533223..534290 | - | 1068 | WP_000080086.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| GE168_RS02590 (534290) | 534290..535360 | - | 1071 | WP_000108977.1 | histidinol-phosphate transaminase | - |
| GE168_RS02595 (535357) | 535357..536661 | - | 1305 | WP_001462576.1 | histidinol dehydrogenase | - |
| GE168_RS02600 (536667) | 536667..537566 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| GE168_RS02605 (537712) | 537712..537762 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| GE168_RS02610 (538045) | 538045..538296 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| GE168_RS02615 (538293) | 538293..538547 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| GE168_RS02620 (538630) | 538630..539454 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| GE168_RS02625 (539500) | 539500..540429 | + | 930 | WP_000811606.1 | LysR substrate-binding domain-containing protein | - |
| GE168_RS02630 (540644) | 540644..540706 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| GE168_RS02635 (540696) | 540696..542054 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| GE168_RS02640 (542233) | 542233..543291 | + | 1059 | WP_000492295.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| GE168_RS02645 (543305) | 543305..543532 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T142055 WP_000767829.1 NZ_CP045524:538293-538547 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T142055 NZ_CP060391:2807-3061 [Psychrobacter sp. KCTC 72983]
TTGATCTTATCTTGGACACAGGATGCGTGGGAGGACTACGAATACTGGCAAAAAACCAGCAAAGAGAAGGTCAAGCAAAT
AAGTAAGCTGATTAAAGCCATCAAACGTGACCCATTTGAGGGTATTGGTAAACCTGAACCACTCAAACACGATCTGGCAG
GCTATTGGTCGCGTCGCATTGATCAAGAGCATAGACTGGTTTATGAGGTTCAAGATGATGCCATTATCATCGTTCAGTGC
CGATATCATTATTAA
TTGATCTTATCTTGGACACAGGATGCGTGGGAGGACTACGAATACTGGCAAAAAACCAGCAAAGAGAAGGTCAAGCAAAT
AAGTAAGCTGATTAAAGCCATCAAACGTGACCCATTTGAGGGTATTGGTAAACCTGAACCACTCAAACACGATCTGGCAG
GCTATTGGTCGCGTCGCATTGATCAAGAGCATAGACTGGTTTATGAGGTTCAAGATGATGCCATTATCATCGTTCAGTGC
CGATATCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT142055 WP_001259255.1 NZ_CP045524:538045-538296 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT142055 NZ_CP060391:2520-2810 [Psychrobacter sp. KCTC 72983]
ATGGATGTTGTGAACTACACTGATTTTAGAAAGGGCCTAGCCAAATATATCGATAAGGTAGATACCGACAAATCGCCGAT
CGTGATTACTAGACAAAACGCCAAACCTGCGGTACTCATGAGTTTAGAAGAGTTTAATTCATATGAGGAAACGCTTCATC
TGCTAAAAAGCCCCACTAATGCCAAGCGCCTCAGACGCTCTATAGCCGATGCTAAGGCGGGTCGTTTAATCGAGCATGAC
ATCAATACGGATGACGCATTATTGACTTGTGATGATGAGGTGGACGCTTGA
ATGGATGTTGTGAACTACACTGATTTTAGAAAGGGCCTAGCCAAATATATCGATAAGGTAGATACCGACAAATCGCCGAT
CGTGATTACTAGACAAAACGCCAAACCTGCGGTACTCATGAGTTTAGAAGAGTTTAATTCATATGAGGAAACGCTTCATC
TGCTAAAAAGCCCCACTAATGCCAAGCGCCTCAGACGCTCTATAGCCGATGCTAAGGCGGGTCGTTTAATCGAGCATGAC
ATCAATACGGATGACGCATTATTGACTTGTGATGATGAGGTGGACGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|