Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 73110..73374 | Replicon | plasmid p5908-2 |
| Accession | NZ_CP045523 | ||
| Organism | Shigella flexneri strain 5908.2 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | GE167_RS23395 | Protein ID | WP_001387489.1 |
| Coordinates | 73222..73374 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 73110..73172 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE167_RS23380 (69212) | 69212..70282 | - | 1071 | WP_000151588.1 | IncI1-type conjugal transfer protein TrbB | - |
| GE167_RS23385 (70301) | 70301..71509 | - | 1209 | WP_000121263.1 | IncI1-type conjugal transfer protein TrbA | - |
| GE167_RS23390 (71816) | 71816..72901 | - | 1086 | WP_000080543.1 | protein finQ | - |
| - (73110) | 73110..73172 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73110) | 73110..73172 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73110) | 73110..73172 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (73110) | 73110..73172 | - | 63 | NuclAT_0 | - | Antitoxin |
| GE167_RS23395 (73222) | 73222..73374 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| GE167_RS23400 (73446) | 73446..73697 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| GE167_RS23405 (73997) | 73997..74293 | + | 297 | WP_001275298.1 | DinQ-like type I toxin DqlB | - |
| GE167_RS24000 (74358) | 74358..74534 | - | 177 | WP_001054898.1 | hypothetical protein | - |
| GE167_RS23410 (74717) | 74717..74926 | - | 210 | WP_001140543.1 | hemolysin expression modulator Hha | - |
| GE167_RS23415 (75024) | 75024..75638 | - | 615 | WP_000578648.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| GE167_RS23420 (75714) | 75714..77882 | - | 2169 | WP_000698360.1 | IncI1-type conjugal transfer membrane protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA1 / ant(3'')-Ia / qacE / sul2 / qnrS1 / blaCTX-M-15 | - | 1..137368 | 137368 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T142050 WP_001387489.1 NZ_CP045523:73222-73374 [Shigella flexneri]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T142050 NZ_CP060388:3660087-3660389 [Sphingobium sp. KCTC 72723]
GTGCCTCGCTTTCGCTTAACGCGCGCCGCAGCCGACGATCTGGCAACCATCTTTCTCAAAGGCATCGAGCAGTTCGGACT
ACCTCAAGCCGACACCTATCACGAAGGTCTGAGCGCGATATTCGCGTTTCTTGCCGAGTATCCCCAGGCTGCTCGATTGC
GGGAGGAAATATCGCCTCCCGTCCGCGTGCATCCCTACAAGGCACATCTGGTGATTTATGACGTGGGAGATGAGGACGAG
GTCATCATTCTGCGTGTCCGGCATGGCAGGGAAGATTGGATGCCCTCGAACTACGACGGCTAG
GTGCCTCGCTTTCGCTTAACGCGCGCCGCAGCCGACGATCTGGCAACCATCTTTCTCAAAGGCATCGAGCAGTTCGGACT
ACCTCAAGCCGACACCTATCACGAAGGTCTGAGCGCGATATTCGCGTTTCTTGCCGAGTATCCCCAGGCTGCTCGATTGC
GGGAGGAAATATCGCCTCCCGTCCGCGTGCATCCCTACAAGGCACATCTGGTGATTTATGACGTGGGAGATGAGGACGAG
GTCATCATTCTGCGTGTCCGGCATGGCAGGGAAGATTGGATGCCCTCGAACTACGACGGCTAG
Antitoxin
Download Length: 63 bp
>AT142050 NZ_CP045523:c73172-73110 [Shigella flexneri]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
