Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3889085..3889812 Replicon chromosome
Accession NZ_CP045522
Organism Shigella flexneri strain 5908.2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GE167_RS19700 Protein ID WP_119182032.1
Coordinates 3889498..3889812 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GE167_RS19695 Protein ID WP_000560266.1
Coordinates 3889085..3889501 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE167_RS19685 (3884445) 3884445..3886796 + 2352 WP_000695506.1 alpha-glucosidase -
GE167_RS19690 (3887022) 3887022..3889040 + 2019 WP_040235166.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
GE167_RS19695 (3889085) 3889085..3889501 - 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
GE167_RS19700 (3889498) 3889498..3889812 - 315 WP_119182032.1 type II toxin-antitoxin system toxin HigB Toxin
GE167_RS19705 (3890097) 3890097..3891233 - 1137 WP_000018657.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
GE167_RS19710 (3891318) 3891318..3891821 + 504 WP_005071012.1 M48 family metallopeptidase -
GE167_RS19715 (3891898) 3891898..3892590 + 693 WP_000942537.1 vancomycin high temperature exclusion protein -
GE167_RS19720 (3892669) 3892669..3893667 + 999 WP_005050984.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12077.07 Da        Isoelectric Point: 10.1027

>T142048 WP_119182032.1 NZ_CP045522:c3889812-3889498 [Shigella flexneri]
MHLITQKALKDAAEKHPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T142048 NZ_CP060388:367652-367975 [Sphingobium sp. KCTC 72723]
ATGAAGTTCCTTGTCGACGCGCAGTTGCCACCTGCCTTGTGCCGATGGCTGCACGAGCAGGGCCATGAAGCCGTGCATGT
TTGCGACATCGGGATGATTGCGGCCAGCGATGTCGAAATTGCTGCGCGCGCCGAAGTGGATGGGGCTGCTCTCGTCAGCA
AGGACGAGGATTTTGTCGTGCTGCGCTTGCCGGATCGGTTCGCGTTGCTGTGGCTGCGGTGCGGGAACGCGACGAACCGG
GCGCTGGTGGGGTGGCTTGAGGCGAGGTGGGCGCGGATTGTGGTGTTGTTGGAGGGTGGGGAGCGGTTGGTGGAAGTGCG
GTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT142048 WP_000560266.1 NZ_CP045522:c3889501-3889085 [Shigella flexneri]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT142048 NZ_CP060388:367422-367655 [Sphingobium sp. KCTC 72723]
ATGACACTTGCAGGCTTTCCCCGTATCGCCGTCGATCCCGCTGTTTGTGGCGGACGGCCTATTGTTGTCGGTACGCGCGT
GCGGGTGAGCGATATATTGGAGATGCTGGCCGGAGGGGCTGGCGTGGACGAGATCGTAGCCGATTTTCCCTATCTGAGCG
CTGATGATGTGCGGGCGGCGTTGGGATATGCAGCCGCTATGGCTGATCATCCCGTGGTGCTTGCTGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References