Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1395560..1396088 | Replicon | chromosome |
| Accession | NZ_CP045522 | ||
| Organism | Shigella flexneri strain 5908.2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | GE167_RS06845 | Protein ID | WP_236743520.1 |
| Coordinates | 1395858..1396088 (-) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q32DW6 |
| Locus tag | GE167_RS06840 | Protein ID | WP_000147081.1 |
| Coordinates | 1395560..1395868 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE167_RS06815 (1390984) | 1390984..1392197 | + | 1214 | WP_171763907.1 | IS3 family transposase | - |
| GE167_RS06820 (1392237) | 1392237..1394585 | + | 2349 | Protein_1342 | toprim domain-containing protein | - |
| GE167_RS06825 (1394660) | 1394660..1394938 | + | 279 | WP_025757756.1 | hypothetical protein | - |
| GE167_RS06830 (1394935) | 1394935..1395345 | + | 411 | WP_000814621.1 | recombination protein NinB | - |
| GE167_RS06835 (1395342) | 1395342..1395518 | + | 177 | WP_001254220.1 | NinE family protein | - |
| GE167_RS06840 (1395560) | 1395560..1395868 | - | 309 | WP_000147081.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| GE167_RS06845 (1395858) | 1395858..1396088 | - | 231 | WP_236743520.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GE167_RS06850 (1396101) | 1396101..1397069 | + | 969 | WP_000961310.1 | Rha family phage regulatory protein | - |
| GE167_RS06855 (1397066) | 1397066..1397299 | + | 234 | WP_000618004.1 | hypothetical protein | - |
| GE167_RS06860 (1397286) | 1397286..1398193 | + | 908 | Protein_1350 | DNA-binding protein | - |
| GE167_RS06865 (1398204) | 1398204..1399082 | + | 879 | WP_000988187.1 | ATP-binding protein | - |
| GE167_RS06870 (1399079) | 1399079..1400326 | + | 1248 | Protein_1352 | replicative DNA helicase | - |
| GE167_RS06875 (1400357) | 1400357..1400572 | - | 216 | Protein_1353 | transposase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | ipaH9.8 / ipaH4.5 | 1378257..1448367 | 70110 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8695.15 Da Isoelectric Point: 10.5308
>T142027 WP_236743520.1 NZ_CP045522:c1396088-1395858 [Shigella flexneri]
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKTQKTPPAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKTQKTPPAERKKAETRMKEVKHDW
Download Length: 231 bp
>T142027 NZ_CP060288:3027356-3027754 [Pseudomonas mendocina]
ATGACAGGGACGATTTTCCGCAAAGGGACTTTGCTAATTCTCAGCGGCCCAGTAGAGCACCTTCATATTGTGATGAATGA
TCCAGTGTACTCCCATGAGCACGGCTGGGATGGTGTACTGGCAGTCAACATATCCTCAATTAAACCTGGCATCTATCATG
ACCCGAGTTGCATTGTGCAGCCCGGGCAGCATCCGTTTGTAAGCAGGGATAGTTGGGTTGTTTATAGAGAAGCAGCCGTA
ATGCGCTGTGATCGCTTGGAATACAAGCTAGCGTCCGGTGAAATTCGAGGGCATCAAACAACAACGGAAGAGCTTTTTGC
TAACGTGCGTGCAGGCTTTGATATTTCTAAAATGGTTCCGCAAAAAATAAAGAGATTTATCAGGGCTCATTCCATTTGA
ATGACAGGGACGATTTTCCGCAAAGGGACTTTGCTAATTCTCAGCGGCCCAGTAGAGCACCTTCATATTGTGATGAATGA
TCCAGTGTACTCCCATGAGCACGGCTGGGATGGTGTACTGGCAGTCAACATATCCTCAATTAAACCTGGCATCTATCATG
ACCCGAGTTGCATTGTGCAGCCCGGGCAGCATCCGTTTGTAAGCAGGGATAGTTGGGTTGTTTATAGAGAAGCAGCCGTA
ATGCGCTGTGATCGCTTGGAATACAAGCTAGCGTCCGGTGAAATTCGAGGGCATCAAACAACAACGGAAGAGCTTTTTGC
TAACGTGCGTGCAGGCTTTGATATTTCTAAAATGGTTCCGCAAAAAATAAAGAGATTTATCAGGGCTCATTCCATTTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11185.94 Da Isoelectric Point: 8.5840
>AT142027 WP_000147081.1 NZ_CP045522:c1395868-1395560 [Shigella flexneri]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT142027 NZ_CP060288:3026865-3027356 [Pseudomonas mendocina]
ATGTCCTACCTGAAGCTGATGAAGCTGCTTTACTTGGCAGATCGTGAATCCATGGATCGTTACAGCGTTCCGATGTCGGA
CGACGCAGCTGTTTCGATGCCGCACGGCCCCGTGCTTTCAACCACTCTGAATCTGATGACAGGTCAAATCGAGTCGCCAT
TCTGGCGAAGCTGGATTTCTCCTGATGCAAATCATGAGGTGAGCTTGAGTCGTCCAGTGAATAGCCTGGAAGATCTCGAC
GAGCTTTCCGAAGCAGATTTTGAAATTCTTGAATTGGTGTGGCAGAAGTTCGGGCACCTGCGACGCTGGGAAATCAGAGA
TTTAACCCACAGAGATTGTCCGGAGTGGGTTGACCCTGGGCGTTCTTCCGCTCCAATCGACCCTCGCGCAGTGTTCACTG
CCCTAGGCAGATCAGAAGAGCAAGCGAACGCTGAGACAAAAGAAATTTTCGAACGCAGAGTTCTTGGACGGGCTGTATCT
GAGTTAATTTAA
ATGTCCTACCTGAAGCTGATGAAGCTGCTTTACTTGGCAGATCGTGAATCCATGGATCGTTACAGCGTTCCGATGTCGGA
CGACGCAGCTGTTTCGATGCCGCACGGCCCCGTGCTTTCAACCACTCTGAATCTGATGACAGGTCAAATCGAGTCGCCAT
TCTGGCGAAGCTGGATTTCTCCTGATGCAAATCATGAGGTGAGCTTGAGTCGTCCAGTGAATAGCCTGGAAGATCTCGAC
GAGCTTTCCGAAGCAGATTTTGAAATTCTTGAATTGGTGTGGCAGAAGTTCGGGCACCTGCGACGCTGGGAAATCAGAGA
TTTAACCCACAGAGATTGTCCGGAGTGGGTTGACCCTGGGCGTTCTTCCGCTCCAATCGACCCTCGCGCAGTGTTCACTG
CCCTAGGCAGATCAGAAGAGCAAGCGAACGCTGAGACAAAAGAAATTTTCGAACGCAGAGTTCTTGGACGGGCTGTATCT
GAGTTAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|