Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 73051..73708 | Replicon | plasmid pSal-5091_DHA |
| Accession | NZ_CP045520 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain Sal-5091 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | GE195_RS23310 | Protein ID | WP_000270043.1 |
| Coordinates | 73051..73401 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | GE195_RS23315 | Protein ID | WP_000124640.1 |
| Coordinates | 73406..73708 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GE195_RS23260 | 68362..68541 | + | 180 | Protein_85 | helix-turn-helix transcriptional regulator | - |
| GE195_RS23265 | 68606..69310 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| GE195_RS23270 | 69525..70022 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| GE195_RS23275 | 70025..70513 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| GE195_RS23280 | 70610..70945 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| GE195_RS23285 | 70960..71430 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| GE195_RS23290 | 71423..71794 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| GE195_RS23295 | 71805..71999 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| GE195_RS23305 | 72340..72888 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| GE195_RS23310 | 73051..73401 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GE195_RS23315 | 73406..73708 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| GE195_RS23320 | 73735..74028 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| GE195_RS23325 | 74116..74388 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| GE195_RS23330 | 74446..74973 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| GE195_RS23340 | 75204..76061 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| GE195_RS23345 | 76048..76278 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| GE195_RS23350 | 76278..76796 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| GE195_RS23355 | 76793..77239 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| GE195_RS23360 | 77239..77598 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| GE195_RS23365 | 77655..78083 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..90138 | 90138 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T142020 WP_000270043.1 NZ_CP045520:73051-73401 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T142020 NZ_CP060282:c161864-161421 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT142020 WP_000124640.1 NZ_CP045520:73406-73708 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT142020 NZ_CP060282:c162091-161861 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|