Detailed information of TA system TA142010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 789199..789716
• Replicon: chromosome
• Accession: NZ_CP045508
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 107105

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GD604_RS03370
• Protein ID: WP_176637025.1
• Coordinates: 789199..789456 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GD604_RS03375
• Protein ID: WP_176630122.1
• Coordinates: 789462..789716 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD604_RS03335	784293..785696	+	1404	WP_176630116.1	glutamate--tRNA ligase	-
GD604_RS03340	785945..786499	+	555	WP_176630117.1	hypothetical protein	-
GD604_RS03345	786747..787586	+	840	WP_176630118.1	hypothetical protein	-
GD604_RS03350	787635..788221	+	587	Protein_658	group II intron reverse transcriptase/maturase	-
GD604_RS03355	788146..788319	+	174	WP_176636768.1	hypothetical protein	-
GD604_RS03360	788499..788726	+	228	WP_176630119.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GD604_RS03365	788723..789121	+	399	WP_176630120.1	type II toxin-antitoxin system VapC family toxin	-
GD604_RS03370	789199..789456	-	258	WP_176637025.1	Txe/YoeB family addiction module toxin	Toxin
GD604_RS03375	789462..789716	-	255	WP_176630122.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GD604_RS03380	789975..790184	-	210	WP_176630123.1	50S ribosomal protein L28	-
GD604_RS03385	790376..790915	+	540	WP_176630124.1	DUF177 domain-containing protein	-
GD604_RS03390	790989..791171	+	183	WP_176630125.1	50S ribosomal protein L32	-
GD604_RS03395	791161..792222	+	1062	WP_176637026.1	phosphate acyltransferase PlsX	-
GD604_RS03400	792240..793238	+	999	WP_176630127.1	ketoacyl-ACP synthase III	-
GD604_RS03405	793417..794160	+	744	WP_176630128.1	3-oxoacyl-[acyl-carrier-protein] reductase	-
GD604_RS03410	794196..794432	+	237	WP_176630129.1	acyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	786747..823538	36791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10149.59 Da
• Isoelectric Point: 9.4583

>T142010 WP_176637025.1 NZ_CP045508:c789456-789199 [Desulfolutivibrio sulfoxidireducens]
MRLVWTPQAWEDYLFWQATDRSKVKRINELIRETLRSPFEGKGKPEALRFDLSGYWSRRITAEHRLIYGVSGDDLVIVAC
RYHYS

Nucleotide

• Length: 258 bp

>T142010 NZ_CP060281:358777-359124 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9142.39 Da
• Isoelectric Point: 6.0643

>AT142010 WP_176630122.1 NZ_CP045508:c789716-789462 [Desulfolutivibrio sulfoxidireducens]
MDAITYSHAREHLAATMDRVCADKAPIVITRQKAQAVVMMSLEEYNAIEETAHLLRNPANAARLRSAVAAARSGDVAEHA
LIED

Nucleotide

• Length: 255 bp

>AT142010 NZ_CP060281:359124-359423 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA