Detailed information of TA system TA142001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 829986..830503
• Replicon: chromosome
• Accession: NZ_CP045506
• Organism: Desulfolutivibrio sulfoxidireducens strain DSM 106783

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GD605_RS03495
• Protein ID: WP_176630121.1
• Coordinates: 829986..830243 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GD605_RS03500
• Protein ID: WP_176630122.1
• Coordinates: 830249..830503 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GD605_RS03465	825079..826482	+	1404	WP_176630116.1	glutamate--tRNA ligase	-
GD605_RS03470	826731..827285	+	555	WP_176630117.1	hypothetical protein	-
GD605_RS03475	827533..828372	+	840	WP_176630118.1	hypothetical protein	-
GD605_RS03480	828421..829106	+	686	Protein_684	hypothetical protein	-
GD605_RS03485	829286..829513	+	228	WP_176630119.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GD605_RS03490	829510..829908	+	399	WP_176630120.1	type II toxin-antitoxin system VapC family toxin	-
GD605_RS03495	829986..830243	-	258	WP_176630121.1	Txe/YoeB family addiction module toxin	Toxin
GD605_RS03500	830249..830503	-	255	WP_176630122.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GD605_RS03505	830762..830971	-	210	WP_176630123.1	50S ribosomal protein L28	-
GD605_RS03510	831163..831702	+	540	WP_176630124.1	DUF177 domain-containing protein	-
GD605_RS03515	831776..831958	+	183	WP_176630125.1	50S ribosomal protein L32	-
GD605_RS03520	831948..833009	+	1062	WP_176630126.1	phosphate acyltransferase PlsX	-
GD605_RS03525	833027..834025	+	999	WP_176630127.1	ketoacyl-ACP synthase III	-
GD605_RS03530	834204..834947	+	744	WP_176630128.1	3-oxoacyl-[acyl-carrier-protein] reductase	-
GD605_RS03535	834983..835219	+	237	WP_176630129.1	acyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	827533..838967	11434

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10121.54 Da
• Isoelectric Point: 8.8867

>T142001 WP_176630121.1 NZ_CP045506:c830243-829986 [Desulfolutivibrio sulfoxidireducens]
MRLVWTPQAWEDYLFWQATDRSKVKQINELIRETLRSPFEGKGKPEALRFDLSGYWSRRITAEHRLIYGVSGDDLVIVAC
RYHYS

Nucleotide

• Length: 258 bp

>T142001 NZ_CP060278:c2307094-2306942 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9142.39 Da
• Isoelectric Point: 6.0643

>AT142001 WP_176630122.1 NZ_CP045506:c830503-830249 [Desulfolutivibrio sulfoxidireducens]
MDAITYSHAREHLAATMDRVCADKAPIVITRQKAQAVVMMSLEEYNAIEETAHLLRNPANAARLRSAVAAARSGDVAEHA
LIED

Nucleotide

• Length: 255 bp

>AT142001 NZ_CP060278:c2307718-2307119 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA