Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2326656..2327253 Replicon chromosome
Accession NZ_CP045504
Organism Desulfovibrio sulfodismutans DSM 3696

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GD606_RS10945 Protein ID WP_163303418.1
Coordinates 2326656..2326934 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GD606_RS10950 Protein ID WP_163303419.1
Coordinates 2326957..2327253 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GD606_RS10915 2321697..2321927 + 231 WP_163302095.1 hypothetical protein -
GD606_RS10920 2321917..2322201 + 285 WP_163302092.1 type II toxin-antitoxin system RelE/ParE family toxin -
GD606_RS10925 2322564..2323499 + 936 WP_163302096.1 virulence RhuM family protein -
GD606_RS10930 2323620..2324855 + 1236 WP_163302093.1 DUF4062 domain-containing protein -
GD606_RS10935 2325105..2326136 - 1032 WP_176629169.1 IS5 family transposase -
GD606_RS10940 2326375..2326524 - 150 WP_163303417.1 hypothetical protein -
GD606_RS10945 2326656..2326934 + 279 WP_163303418.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GD606_RS10950 2326957..2327253 + 297 WP_163303419.1 HigA family addiction module antidote protein Antitoxin
GD606_RS10955 2327293..2327712 - 420 WP_163303420.1 bacteriohemerythrin -
GD606_RS10960 2327725..2330490 - 2766 WP_163303421.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10278.74 Da        Isoelectric Point: 10.8036

>T141995 WP_163303418.1 NZ_CP045504:2326656-2326934 [Desulfovibrio sulfodismutans DSM 3696]
MIRRFRHKGLERLFLSGDQSGVAGQHVRKLSHILAMLHASASPEGMNLPGFRLHQLKGDRKGSWAVSVSGNWRIVFTFHG
GDATDVDLVDYH

Download         Length: 279 bp

>T141995 NZ_CP060277:62329-62745 [Serratia ureilytica]
GTGAACAAGATCTATATGCTCGACACCAACATTTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCCGTGATCAAACGCCT
GGAGCAGGCGGTGCTGCGTAACCACCGCATAGTGGTCTCAGCCATCACCTACGCTGAAATGCGTTTTGGGGCGATCGGCA
AGAAAGCTTCACCGCACCACGCGCCGCTGGTTGACGCCTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGGGCA
GCCGTGGACGCCACCACCGAAATTAAGGCCGCCCTGGCCGCGGCCGGGACGCCGATCGGCCCGAACGACACAGCGATCGC
TGGCCATGCCATTGCCGCTGGCGCCATTCTGGTGACGAATAATACGCGGGAATTTGCGCGAGTGCCGGACCTAACGCTGG
AAGACTGGGTCAGATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10871.58 Da        Isoelectric Point: 10.0091

>AT141995 WP_163303419.1 NZ_CP045504:2326957-2327253 [Desulfovibrio sulfodismutans DSM 3696]
MHMHSPPHPGEIIRDQCLEPLRLTVSEAARGLGVTRKTFSELVNGRSGVSPEMALRLAKAFGSTPETWLTLQLQYDLAKA
RTKAQDMVVRRFIEPSAA

Download         Length: 297 bp

>AT141995 NZ_CP060277:62102-62332 [Serratia ureilytica]
ATGCGAATTGTATCGATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCTCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGCCCGCGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCACGCAGTTGG
AAAAGGCCGATCCGGGCTTTTTGGCGGAGCGGGCGGATGTGGTCAGCGACGAAGGACGATTTGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References