Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4479720..4480322 Replicon chromosome
Accession NZ_CP045486
Organism Enterobacter cloacae strain 99101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GEA59_RS21120 Protein ID WP_203465377.1
Coordinates 4480011..4480322 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GEA59_RS21115 Protein ID WP_203465376.1
Coordinates 4479720..4480010 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA59_RS21100 4477218..4478120 + 903 WP_203465375.1 formate dehydrogenase subunit beta -
GEA59_RS21105 4478117..4478752 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
GEA59_RS21110 4478749..4479678 + 930 WP_023315053.1 formate dehydrogenase accessory protein FdhE -
GEA59_RS21115 4479720..4480010 - 291 WP_203465376.1 helix-turn-helix domain-containing protein Antitoxin
GEA59_RS21120 4480011..4480322 - 312 WP_203465377.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEA59_RS21125 4480471..4481412 - 942 WP_063449681.1 fatty acid biosynthesis protein FabY -
GEA59_RS21130 4481457..4481894 - 438 WP_203465378.1 D-tyrosyl-tRNA(Tyr) deacylase -
GEA59_RS21135 4481891..4482772 - 882 WP_063449679.1 virulence factor BrkB family protein -
GEA59_RS21140 4482766..4483365 - 600 WP_063449678.1 glucose-1-phosphatase -
GEA59_RS21145 4483484..4484284 - 801 WP_063865422.1 DeoR/GlpR family DNA-binding transcription regulator -
GEA59_RS21150 4484319..4485215 - 897 WP_203465379.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12202.20 Da        Isoelectric Point: 9.6746

>T141962 WP_203465377.1 NZ_CP045486:c4480322-4480011 [Enterobacter cloacae]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTREFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T141962 NZ_CP060263:1620624-1620881 [Dickeya zeae]
ATGCCTGAGATTGACAGACTGGCAGGGTTAATCTTCTATTTGTACTTTTACGATGATGAGCGGCACCACTTGCCGCATGT
GCATGTCTGCTACGGCAATCATGAACTTATCATCAGTATTCGTACCGGAACCGAGATAGAGGGATATCTGCCAAATACCA
AACGTAAGCTGGCGATTGCCCATATCATGGCGCATCGTGAGCAATTGCTGAGTATGTGGGCACAGGCGGTTATCGGGAAG
AATCCGGGAAAATTGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10662.16 Da        Isoelectric Point: 10.5888

>AT141962 WP_203465376.1 NZ_CP045486:c4480010-4479720 [Enterobacter cloacae]
MDKALFERLTQSVGQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT141962 NZ_CP060263:1620889-1621374 [Dickeya zeae]
ATGCATAAGATTGTAGATGTTGACGTGACTGGTGACTTTTCGTTGCGTCTGACTTATGACGATGGCCTGATAAGCGACGT
TAACCTGTATCACTATGCTTCACATTCTGTGTTTTCGCATGCCAGCCAGTTTATTCGATTTGGGTTATTACCTGATGGTT
CGCTGGAATGGCCGGATATCACGCTCTCTTCGTCCGCATTACGGGAAAAGGGGACGTATGTTGGCCACACCCTGGCGGTG
AGGGAGCGAAATTTTGCCGATATTATCTCCCGAGCTTTCTATGATGCCGTGATTGAGAACCGGCCAGAAATTCTGCAGGC
GGCGCTGAAAACCGCAGTAGACAAACATGGCAACAGTACGGTGGCCAAAGAAGCGGGAGCCAAAAGCCGTACCAGCTTGT
ATAAATCGCTGAATAAAAACACTAATGTCAGCCTGGCGACGGTAGTTAGCCTGGCCCATACCGTGTTGCAGTTGGAAGAG
AAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References