Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 90387..91033 Replicon chromosome
Accession NZ_CP045486
Organism Enterobacter cloacae strain 99101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GEA59_RS00460 Protein ID WP_203465442.1
Coordinates 90683..91033 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GEA59_RS00455 Protein ID WP_063868738.1
Coordinates 90387..90686 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEA59_RS00430 85855..86439 - 585 WP_112792086.1 type 1 fimbrial protein -
GEA59_RS00435 86492..87094 - 603 WP_063868730.1 response regulator transcription factor -
GEA59_RS00440 87930..88718 + 789 WP_107534385.1 winged helix-turn-helix domain-containing protein -
GEA59_RS00445 88720..89199 + 480 WP_203465441.1 hypothetical protein -
GEA59_RS00450 89441..90322 + 882 WP_203466135.1 helix-turn-helix domain-containing protein -
GEA59_RS00455 90387..90686 - 300 WP_063868738.1 XRE family transcriptional regulator Antitoxin
GEA59_RS00460 90683..91033 - 351 WP_203465442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEA59_RS00465 91657..91998 - 342 WP_203465443.1 SymE family type I addiction module toxin -
GEA59_RS00470 92124..92315 + 192 WP_203465444.1 toxin-antitoxin system HicB family antitoxin -
GEA59_RS00475 92424..94379 - 1956 WP_203465445.1 RNA-directed DNA polymerase -
GEA59_RS00480 94382..95614 - 1233 WP_203465446.1 RNA-directed DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 86492..96252 9760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(42-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13412.53 Da        Isoelectric Point: 8.8416

>T141949 WP_203465442.1 NZ_CP045486:c91033-90683 [Enterobacter cloacae]
MWTVVLSKVFEQWLLEQEEGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFALDPVRQAI
VLCAGDKRNDKAFYEKLIRIADAEFNLHLTSLEAAK

Download         Length: 351 bp

>T141949 NZ_CP060244:328920-329174 [Entomobacter blattae]
ATTATGTGGGAAATAAGATTTTCTGAAACAGCTAGTAAAGAATTCAGTAAGCTGGATAAACCAGTGGCCAAAAGGCTTAT
GAACTTTTTGGAAGAACGCGTTGTCACTTTAGAAGACCCTCGTAACCTTGGTAAAGCTCTTCGCGGCCATTTAGGTGAAC
TTTGGTCTTACAGAGTGGGAGACTTTCGTATCATTGCTGATATTCAGGACAAAAAGCTCTGCATCCTTATTCTGAAGACG
GGACACAGAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11119.83 Da        Isoelectric Point: 6.4714

>AT141949 WP_063868738.1 NZ_CP045486:c90686-90387 [Enterobacter cloacae]
VKTLNEVIASRSSESQQRIQEMAEEMFLETGLQLLREELQLSQKHVADLMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKRVAFHL

Download         Length: 300 bp

>AT141949 NZ_CP060244:328693-328914 [Entomobacter blattae]
ATGACAACCACAGTTCGCCTTAACCAAAATATTGAAGAGCGGCTTGACTTTCTGGCAAAACAGACAGGCCGAACCAAAAC
CTATTATATTGCCCAACTAATTGAAAACGGTTTGGATGAGCTGGAAGATTATTATCTCGCTGCCGATGTTCTGGAAAAAA
TCCGAAAAGGAAAAGAAAAAACCATTTCCTCTTCAGACCTTAAAAAGACTCTTGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References