141919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2817888..2818302 Replicon chromosome
Accession NZ_CP045472
Organism Staphylococcus aureus strain ZY05

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GAY69_RS13880 Protein ID WP_001065099.1
Coordinates 2817888..2818139 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GAY69_RS14145 Protein ID WP_000028424.1
Coordinates 2818129..2818302 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY69_RS13825 2813106..2813549 + 444 WP_001099007.1 single-stranded DNA-binding protein -
GAY69_RS13830 2813561..2814235 + 675 WP_000057262.1 hypothetical protein -
GAY69_RS14140 2814232..2814381 + 150 WP_001081076.1 hypothetical protein -
GAY69_RS13835 2814374..2814655 - 282 WP_000414755.1 hypothetical protein -
GAY69_RS13840 2814721..2815491 + 771 WP_000190254.1 conserved phage C-terminal domain-containing protein -
GAY69_RS13845 2815501..2816280 + 780 WP_000803062.1 ATP-binding protein -
GAY69_RS13850 2816274..2816432 + 159 WP_000256594.1 hypothetical protein -
GAY69_RS13855 2816445..2816666 + 222 WP_001123669.1 DUF3269 family protein -
GAY69_RS13860 2816676..2817080 + 405 WP_000049798.1 DUF1064 domain-containing protein -
GAY69_RS13865 2817085..2817270 + 186 WP_001187236.1 DUF3113 family protein -
GAY69_RS13870 2817271..2817627 + 357 WP_000029366.1 hypothetical protein -
GAY69_RS13875 2817631..2817873 + 243 WP_000131388.1 phi PVL orf 51-like protein -
GAY69_RS13880 2817888..2818139 + 252 WP_001065099.1 DUF1024 family protein Toxin
GAY69_RS14145 2818129..2818302 + 174 WP_000028424.1 hypothetical protein Antitoxin
GAY69_RS13885 2818303..2818584 + 282 WP_000454994.1 hypothetical protein -
GAY69_RS14150 2818585..2818746 + 162 WP_000889683.1 hypothetical protein -
GAY69_RS13890 2818761..2819267 + 507 WP_001061834.1 dUTPase -
GAY69_RS13895 2819304..2819549 + 246 WP_001282074.1 hypothetical protein -
GAY69_RS13900 2819546..2819734 + 189 WP_000195782.1 DUF1381 domain-containing protein -
GAY69_RS13905 2819709..2819909 + 201 WP_001125015.1 hypothetical protein -
GAY69_RS13910 2819912..2820061 + 150 WP_000237868.1 transcriptional activator RinB -
GAY69_RS13915 2820220..2820870 + 651 WP_001005262.1 hypothetical protein -
GAY69_RS13920 2820870..2821070 + 201 WP_000265043.1 DUF1514 family protein -
GAY69_RS13925 2821098..2821514 + 417 WP_000590122.1 hypothetical protein -
GAY69_RS13930 2821746..2822045 + 300 WP_000988330.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T141919 WP_001065099.1 NZ_CP045472:2817888-2818139 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T141919 NZ_CP060201:c5668744-5668394 [Pseudomonas protegens]
ATGAATGCTCTGTTTATTGAACTGCCGGCATTTGCACGATACCGAAGGGACTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAGTTGCTGCGCCACCCGCACGCGGGTGTTCTGATCCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCGTCG
ATGAGCGACGCAACAAGGGCAAGCGTGGCGGGTTGAGGGTGATTTATTACTGGTGGTCCGGAGGGGCGCAGTTCTGGCTC
TTCACCCTGTTCGACAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAACTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGAAGACATGACCAAACGTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT141919 WP_000028424.1 NZ_CP045472:2818129-2818302 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT141919 NZ_CP060201:c5668407-5668090 [Pseudomonas protegens]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAGGGCATCGACGCCCTCACCCAGGAACGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAACTCGACAAGCTGCCCCCCATCACCGCCGCCGAGGTGATGAACATCCGCCAGCAACTCAACC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCACGCCC
AATGCCCAGGCCACTACCCTGATCCGCCTGGTGGAACGCTACCCCGACACGGTGGAGCGCCTCGCTTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References