Detailed information of TA system TA141912

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2209388..2209651
• Replicon: chromosome
• Accession: NZ_CP045472
• Organism: Staphylococcus aureus strain ZY05

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: GAY69_RS10610
• Protein ID: WP_001802298.1
• Coordinates: 2209388..2209492 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2209487..2209651 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAY69_RS10585	2204782..2205564	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
GAY69_RS10590	2205632..2206489	+	858	WP_000370919.1	Cof-type HAD-IIB family hydrolase	-
GAY69_RS10595	2207184..2207276	-	93	WP_031844941.1	hypothetical protein	-
GAY69_RS10600	2207565..2208701	+	1137	Protein_2073	SAP domain-containing protein	-
GAY69_RS10605	2208744..2209227	+	484	Protein_2074	recombinase family protein	-
GAY69_RS10610	2209388..2209492	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2209487..2209651	-	165	-	-	Antitoxin
GAY69_RS10615	2209941..2211032	-	1092	WP_000495695.1	hypothetical protein	-
GAY69_RS10620	2211298..2212275	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
GAY69_RS10625	2212277..2212597	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
GAY69_RS10630	2212749..2213414	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T141912 WP_001802298.1 NZ_CP045472:2209388-2209492 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T141912 NZ_CP060199:66191-66718 [Aminobacter sp. MDW-2]
GTGAACGTTCCGCCATGGCATGAGGCGGCGATCGCCCGGTCCCACGATCGGAAAGCCTTTGATTGCGGCGACGTCGAGAT
GAATGGCTTTCTGCAGCGGTTCGCGCGCCAGGGACACGAGCAGAATGCCGTTAAGACCTACTGTGCGGTTCCTGATGATG
CGCCCACCAGGGTTCTGGGCTTCTACAGTCTGGCGCCGGCCTCTGTCGAACATGATGCGGTTCCTGCCGCGATGACGAAG
GGCATGGCGCGCCACGCCGTGCCGGGTTTTCTTCTGGCGCGGCTTGCCGTCGACCAATCGCTGGCGGGCAGGGGGCTTGG
GGGTCAGCTTCTGCTGGCGGCCGCCCTGCGCTGCATCCGCGTCACCGTGGAAGTCGGCGGCGTACTGATGATCATCGACG
CCAAAAACGAGCGGGCTGCGAATTGGTATGCGCGCTACGGCGCCGAGCCGCTGAAGGATCGCCCGCTGACGCTTGTCGTG
CCACTCGCGACCTTTGCCAAAGCCCTGGAGGCCACCGGGCACCTCTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT141912 NZ_CP045472:c2209651-2209487 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin