141911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1947690..1948207 Replicon chromosome
Accession NZ_CP045472
Organism Staphylococcus aureus strain ZY05

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag GAY69_RS09270 Protein ID WP_000113263.1
Coordinates 1947941..1948207 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag GAY69_RS09265 Protein ID WP_000584499.1
Coordinates 1947690..1947941 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY69_RS09235 1943390..1944109 + 720 WP_000479576.1 amino acid ABC transporter permease -
GAY69_RS09240 1944106..1944837 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
GAY69_RS09245 1944934..1946184 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
GAY69_RS09250 1946439..1946801 + 363 WP_000819839.1 DUF4467 domain-containing protein -
GAY69_RS09255 1946820..1947419 + 600 WP_000162810.1 DsbA family protein -
GAY69_RS09260 1947426..1947517 + 92 Protein_1814 hypothetical protein -
GAY69_RS09265 1947690..1947941 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GAY69_RS09270 1947941..1948207 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
GAY69_RS09275 1948501..1950048 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
GAY69_RS09280 1950234..1950701 + 468 WP_000153338.1 SRPBCC domain-containing protein -
GAY69_RS09285 1950788..1950970 + 183 WP_000079140.1 hypothetical protein -
GAY69_RS09290 1951174..1951998 + 825 WP_000594633.1 formate/nitrite transporter family protein -
GAY69_RS09295 1952411..1952947 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T141911 WP_000113263.1 NZ_CP045472:1947941-1948207 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T141911 NZ_CP060198:c83445-82927 [Aminobacter sp. MDW-2]
ATGCCTGAAGCCGCCCTGCGTCAGCAGCGAACCTTGTGGCGGGCCTTCGTGCCGCGCTGGGCGCATATGCCGCTTTCGGG
CGAGGGCGCTGCGCGTTTCGGCGGGCGCTGGAACCCGGTAGGATCGCCGACGCTGTATGCGGCCTGTGAGCTGTCGACCG
CCTGGGCCGAATACAACCAGGGTTTTGTCCAGCATCCGGCGCTGATCGCCCAGCTCGAGCTGTCGGACGCGAGGCTGGCC
GACCTGACCGATGCCGCGATGCTGGACGAACTCGGCATCGATGCCGGCATTCACAGATGCGAGTGGCGTTCCGATCTCGA
CGACGGCAGGGCACCGCAAACCCATCTGCTGCAGCAGCGCCTGCTCACCGAAGGCTTTGACGGCGTCGTCTATCCGTCCT
TCATGTCGCCCGGCGGCAGTTGCGTAGCATTGTGGCGCTGGAACGGTCCGGGCCAGCCGTCGCTCAAGGTTATAGATCCT
GATCAGCGCCTGCCCAAGACGCAGGCCTCCTGGCTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT141911 WP_000584499.1 NZ_CP045472:1947690-1947941 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT141911 NZ_CP060198:c83809-83438 [Aminobacter sp. MDW-2]
ATGGCAGCTCAGAGTTTGGGAATGTCGGCGGCCCATTTCGGTGAGGCCCGGTCGCAGTTTCTCTCGGCTCGCCGCGTGTC
GGAACTGCTGGGTGTCACCCAGGCCGACCTGGCCCGGCTCGTTGGCGTTGCCCGCAACACGCTGACGGCGCGCTCCGGAG
CACGCAAGGTCGACCAGGCGCTCAGCCCCGTTGTCCGCATCCTGGCGATGGCCGCCGAGATGGCGGGCGACGAAAGCCGC
GCGGCGATCTGGTTCAAGCATCAGCCCATCCCGGGCTGGGCCGGCAAGACGGCCTATGACCTGGTCGGCGAGGGCAAGGC
GGACAAGGTTCTGGCCTATCTGGAGGCGGTGCGCTCCGGCGTTTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References