Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1947690..1948207 | Replicon | chromosome |
| Accession | NZ_CP045472 | ||
| Organism | Staphylococcus aureus strain ZY05 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | GAY69_RS09270 | Protein ID | WP_000113263.1 |
| Coordinates | 1947941..1948207 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | GAY69_RS09265 | Protein ID | WP_000584499.1 |
| Coordinates | 1947690..1947941 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GAY69_RS09235 | 1943390..1944109 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| GAY69_RS09240 | 1944106..1944837 | + | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| GAY69_RS09245 | 1944934..1946184 | - | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| GAY69_RS09250 | 1946439..1946801 | + | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| GAY69_RS09255 | 1946820..1947419 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| GAY69_RS09260 | 1947426..1947517 | + | 92 | Protein_1814 | hypothetical protein | - |
| GAY69_RS09265 | 1947690..1947941 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GAY69_RS09270 | 1947941..1948207 | + | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| GAY69_RS09275 | 1948501..1950048 | + | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| GAY69_RS09280 | 1950234..1950701 | + | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| GAY69_RS09285 | 1950788..1950970 | + | 183 | WP_000079140.1 | hypothetical protein | - |
| GAY69_RS09290 | 1951174..1951998 | + | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| GAY69_RS09295 | 1952411..1952947 | + | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T141911 WP_000113263.1 NZ_CP045472:1947941-1948207 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T141911 NZ_CP060198:c83445-82927 [Aminobacter sp. MDW-2]
ATGCCTGAAGCCGCCCTGCGTCAGCAGCGAACCTTGTGGCGGGCCTTCGTGCCGCGCTGGGCGCATATGCCGCTTTCGGG
CGAGGGCGCTGCGCGTTTCGGCGGGCGCTGGAACCCGGTAGGATCGCCGACGCTGTATGCGGCCTGTGAGCTGTCGACCG
CCTGGGCCGAATACAACCAGGGTTTTGTCCAGCATCCGGCGCTGATCGCCCAGCTCGAGCTGTCGGACGCGAGGCTGGCC
GACCTGACCGATGCCGCGATGCTGGACGAACTCGGCATCGATGCCGGCATTCACAGATGCGAGTGGCGTTCCGATCTCGA
CGACGGCAGGGCACCGCAAACCCATCTGCTGCAGCAGCGCCTGCTCACCGAAGGCTTTGACGGCGTCGTCTATCCGTCCT
TCATGTCGCCCGGCGGCAGTTGCGTAGCATTGTGGCGCTGGAACGGTCCGGGCCAGCCGTCGCTCAAGGTTATAGATCCT
GATCAGCGCCTGCCCAAGACGCAGGCCTCCTGGCTTTAG
ATGCCTGAAGCCGCCCTGCGTCAGCAGCGAACCTTGTGGCGGGCCTTCGTGCCGCGCTGGGCGCATATGCCGCTTTCGGG
CGAGGGCGCTGCGCGTTTCGGCGGGCGCTGGAACCCGGTAGGATCGCCGACGCTGTATGCGGCCTGTGAGCTGTCGACCG
CCTGGGCCGAATACAACCAGGGTTTTGTCCAGCATCCGGCGCTGATCGCCCAGCTCGAGCTGTCGGACGCGAGGCTGGCC
GACCTGACCGATGCCGCGATGCTGGACGAACTCGGCATCGATGCCGGCATTCACAGATGCGAGTGGCGTTCCGATCTCGA
CGACGGCAGGGCACCGCAAACCCATCTGCTGCAGCAGCGCCTGCTCACCGAAGGCTTTGACGGCGTCGTCTATCCGTCCT
TCATGTCGCCCGGCGGCAGTTGCGTAGCATTGTGGCGCTGGAACGGTCCGGGCCAGCCGTCGCTCAAGGTTATAGATCCT
GATCAGCGCCTGCCCAAGACGCAGGCCTCCTGGCTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT141911 WP_000584499.1 NZ_CP045472:1947690-1947941 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT141911 NZ_CP060198:c83809-83438 [Aminobacter sp. MDW-2]
ATGGCAGCTCAGAGTTTGGGAATGTCGGCGGCCCATTTCGGTGAGGCCCGGTCGCAGTTTCTCTCGGCTCGCCGCGTGTC
GGAACTGCTGGGTGTCACCCAGGCCGACCTGGCCCGGCTCGTTGGCGTTGCCCGCAACACGCTGACGGCGCGCTCCGGAG
CACGCAAGGTCGACCAGGCGCTCAGCCCCGTTGTCCGCATCCTGGCGATGGCCGCCGAGATGGCGGGCGACGAAAGCCGC
GCGGCGATCTGGTTCAAGCATCAGCCCATCCCGGGCTGGGCCGGCAAGACGGCCTATGACCTGGTCGGCGAGGGCAAGGC
GGACAAGGTTCTGGCCTATCTGGAGGCGGTGCGCTCCGGCGTTTATGCCTGA
ATGGCAGCTCAGAGTTTGGGAATGTCGGCGGCCCATTTCGGTGAGGCCCGGTCGCAGTTTCTCTCGGCTCGCCGCGTGTC
GGAACTGCTGGGTGTCACCCAGGCCGACCTGGCCCGGCTCGTTGGCGTTGCCCGCAACACGCTGACGGCGCGCTCCGGAG
CACGCAAGGTCGACCAGGCGCTCAGCCCCGTTGTCCGCATCCTGGCGATGGCCGCCGAGATGGCGGGCGACGAAAGCCGC
GCGGCGATCTGGTTCAAGCATCAGCCCATCCCGGGCTGGGCCGGCAAGACGGCCTATGACCTGGTCGGCGAGGGCAAGGC
GGACAAGGTTCTGGCCTATCTGGAGGCGGTGCGCTCCGGCGTTTATGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|