Detailed information of TA system TA141903

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2454496..2454680
• Replicon: chromosome
• Accession: NZ_CP045468
• Organism: Staphylococcus aureus strain SAW1

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: GBR75_RS12145
• Protein ID: WP_000482647.1
• Coordinates: 2454573..2454680 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2454496..2454556 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBR75_RS12130	2450006..2450173	-	168	WP_031845053.1	hypothetical protein	-
GBR75_RS12135	2450404..2452137	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
GBR75_RS12140	2452162..2453925	-	1764	WP_001064822.1	ABC transporter ATP-binding protein/permease	-
-	2454496..2454556	+	61	-	-	Antitoxin
GBR75_RS12145	2454573..2454680	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
GBR75_RS12150	2454813..2455199	-	387	WP_000779353.1	flippase GtxA	-
GBR75_RS12155	2455467..2456609	+	1143	WP_001176863.1	glycerate kinase	-
GBR75_RS12160	2456669..2457328	+	660	WP_000831298.1	membrane protein	-
GBR75_RS12165	2457511..2458722	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
GBR75_RS12170	2458845..2459318	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T141903 WP_000482647.1 NZ_CP045468:c2454680-2454573 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T141903 NZ_CP060170:c73498-73193 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Nucleotide

• Length: 61 bp

>AT141903 NZ_CP045468:2454496-2454556 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin