Detailed information of TA system TA141902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2429226..2429743
• Replicon: chromosome
• Accession: NZ_CP045468
• Organism: Staphylococcus aureus strain SAW1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: GBR75_RS12010
• Protein ID: WP_000113263.1
• Coordinates: 2429226..2429492 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: GBR75_RS12015
• Protein ID: WP_000584499.1
• Coordinates: 2429492..2429743 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBR75_RS11985	2424486..2425022	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
GBR75_RS11990	2425435..2426259	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
GBR75_RS11995	2426463..2426645	-	183	WP_000079140.1	hypothetical protein	-
GBR75_RS12000	2426732..2427199	-	468	WP_000153338.1	SRPBCC domain-containing protein	-
GBR75_RS12005	2427385..2428932	-	1548	WP_000727757.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
GBR75_RS12010	2429226..2429492	-	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
GBR75_RS12015	2429492..2429743	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GBR75_RS12020	2429915..2430006	-	92	Protein_2314	hypothetical protein	-
GBR75_RS12025	2430013..2430612	-	600	WP_000162810.1	DsbA family protein	-
GBR75_RS12030	2430631..2430993	-	363	WP_000819839.1	DUF4467 domain-containing protein	-
GBR75_RS12035	2431248..2432498	+	1251	WP_001012236.1	FemA/FemB family glycyltransferase FmhA	-
GBR75_RS12040	2432595..2433326	-	732	WP_000615464.1	amino acid ABC transporter ATP-binding protein	-
GBR75_RS12045	2433323..2434042	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T141902 WP_000113263.1 NZ_CP045468:c2429492-2429226 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T141902 NZ_CP060170:6966-7364 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT141902 WP_000584499.1 NZ_CP045468:c2429743-2429492 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT141902 NZ_CP060170:6739-6966 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60