Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2165582..2165799 Replicon chromosome
Accession NZ_CP045468
Organism Staphylococcus aureus strain SAW1

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag GBR75_RS10660 Protein ID WP_001802298.1
Coordinates 2165695..2165799 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2165582..2165637 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBR75_RS10640 2161773..2162438 - 666 WP_001024088.1 SDR family oxidoreductase -
GBR75_RS10645 2162590..2162910 + 321 WP_000139802.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
GBR75_RS10650 2162912..2163889 + 978 WP_155560256.1 CDF family zinc efflux transporter CzrB -
GBR75_RS10655 2164155..2165246 + 1092 WP_160210538.1 transcriptional regulator -
- 2165582..2165637 + 56 - - Antitoxin
GBR75_RS10660 2165695..2165799 - 105 WP_001802298.1 hypothetical protein Toxin
GBR75_RS10665 2165960..2166443 - 484 Protein_2051 recombinase family protein -
GBR75_RS10670 2166486..2166863 - 378 Protein_2052 DNA-binding protein -
GBR75_RS10675 2166925..2167686 - 762 WP_001066124.1 IS21-like element helper ATPase IstB -
GBR75_RS10680 2167679..2168971 - 1293 WP_000777467.1 IS21 family transposase -
GBR75_RS10685 2169064..2169828 - 765 Protein_2055 SAP domain-containing protein -
GBR75_RS10690 2170117..2170209 + 93 WP_031844941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2166925..2167689 764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T141901 WP_001802298.1 NZ_CP045468:c2165799-2165695 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T141901 NZ_CP060160:1116810-1116980 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin


Download         Length: 56 bp

>AT141901 NZ_CP045468:2165582-2165637 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References