Detailed information of TA system TA141900

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2165536..2165799
• Replicon: chromosome
• Accession: NZ_CP045468
• Organism: Staphylococcus aureus strain SAW1

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: GBR75_RS10660
• Protein ID: WP_001802298.1
• Coordinates: 2165695..2165799 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2165536..2165700 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBR75_RS10640	2161773..2162438	-	666	WP_001024088.1	SDR family oxidoreductase	-
GBR75_RS10645	2162590..2162910	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
GBR75_RS10650	2162912..2163889	+	978	WP_155560256.1	CDF family zinc efflux transporter CzrB	-
GBR75_RS10655	2164155..2165246	+	1092	WP_160210538.1	transcriptional regulator	-
-	2165536..2165700	+	165	-	-	Antitoxin
GBR75_RS10660	2165695..2165799	-	105	WP_001802298.1	hypothetical protein	Toxin
GBR75_RS10665	2165960..2166443	-	484	Protein_2051	recombinase family protein	-
GBR75_RS10670	2166486..2166863	-	378	Protein_2052	DNA-binding protein	-
GBR75_RS10675	2166925..2167686	-	762	WP_001066124.1	IS21-like element helper ATPase IstB	-
GBR75_RS10680	2167679..2168971	-	1293	WP_000777467.1	IS21 family transposase	-
GBR75_RS10685	2169064..2169828	-	765	Protein_2055	SAP domain-containing protein	-
GBR75_RS10690	2170117..2170209	+	93	WP_031844941.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2166925..2167689	764

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T141900 WP_001802298.1 NZ_CP045468:c2165799-2165695 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T141900 NZ_CP060160:1014198-1014521 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT141900 NZ_CP045468:2165536-2165700 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin