Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1891836..1892259 Replicon chromosome
Accession NZ_CP045468
Organism Staphylococcus aureus strain SAW1

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag GBR75_RS09055 Protein ID WP_001065091.1
Coordinates 1892008..1892259 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag GBR75_RS09050 Protein ID WP_000028422.1
Coordinates 1891836..1892018 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBR75_RS09005 1887222..1888883 - 1662 WP_000625088.1 terminase large subunit -
GBR75_RS09010 1888880..1889224 - 345 WP_000402904.1 hypothetical protein -
GBR75_RS09015 1889354..1889653 - 300 WP_000988336.1 HNH endonuclease -
GBR75_RS09020 1889885..1890301 - 417 WP_000590122.1 hypothetical protein -
GBR75_RS09025 1890329..1890529 - 201 WP_000265043.1 DUF1514 family protein -
GBR75_RS09030 1890529..1890678 - 150 WP_000595265.1 transcriptional activator RinB -
GBR75_RS09035 1890675..1891061 - 387 WP_000592207.1 hypothetical protein -
GBR75_RS09040 1891058..1891264 - 207 WP_000195803.1 DUF1381 domain-containing protein -
GBR75_RS09045 1891301..1891843 - 543 WP_000185660.1 dUTP pyrophosphatase -
GBR75_RS09050 1891836..1892018 - 183 WP_000028422.1 hypothetical protein Antitoxin
GBR75_RS09055 1892008..1892259 - 252 WP_001065091.1 DUF1024 family protein Toxin
GBR75_RS14140 1892252..1892416 - 165 WP_000990744.1 hypothetical protein -
GBR75_RS09060 1892431..1892673 - 243 WP_000131366.1 hypothetical protein -
GBR75_RS09065 1892677..1893045 - 369 WP_000101274.1 hypothetical protein -
GBR75_RS09070 1893058..1893367 - 310 Protein_1778 RusA family crossover junction endodeoxyribonuclease -
GBR75_RS09075 1893376..1893594 - 219 WP_000338531.1 hypothetical protein -
GBR75_RS09080 1893601..1894485 - 885 WP_000148316.1 DnaD domain protein -
GBR75_RS09085 1894515..1894985 - 471 WP_000934764.1 single-stranded DNA-binding protein -
GBR75_RS09090 1894986..1895603 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
GBR75_RS09095 1895684..1896604 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / chp / sak / sea 1861298..1928533 67235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T141896 WP_001065091.1 NZ_CP045468:c1892259-1892008 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T141896 NZ_CP060159:c2487300-2486992 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATAACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT141896 WP_000028422.1 NZ_CP045468:c1892018-1891836 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT141896 NZ_CP060159:c2487603-2487304 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References