Detailed information of TA system TA141892

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1868525..1868824
• Replicon: chromosome
• Accession: NZ_CP045468
• Organism: Staphylococcus aureus strain SAW1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: GBR75_RS08910
• Protein ID: WP_011447039.1
• Coordinates: 1868648..1868824 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1868525..1868580 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBR75_RS08870	1863855..1864115	+	261	WP_001791826.1	hypothetical protein	-
GBR75_RS08875	1864168..1864518	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
GBR75_RS08880	1865203..1865653	+	451	Protein_1739	chemotaxis-inhibiting protein CHIPS	-
GBR75_RS08885	1865748..1866083	-	336	Protein_1740	SH3 domain-containing protein	-
GBR75_RS08890	1866733..1867224	-	492	WP_000919350.1	staphylokinase	-
GBR75_RS08895	1867415..1868170	-	756	WP_000861038.1	CHAP domain-containing protein	-
GBR75_RS08900	1868182..1868436	-	255	WP_000611512.1	phage holin	-
GBR75_RS08905	1868488..1868595	+	108	WP_001791821.1	hypothetical protein	-
-	1868517..1868656	+	140	NuclAT_0	-	-
-	1868517..1868656	+	140	NuclAT_0	-	-
-	1868517..1868656	+	140	NuclAT_0	-	-
-	1868517..1868656	+	140	NuclAT_0	-	-
-	1868525..1868580	+	56	-	-	Antitoxin
GBR75_RS08910	1868648..1868824	-	177	WP_011447039.1	putative holin-like toxin	Toxin
GBR75_RS08915	1868933..1869706	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
GBR75_RS08920	1870127..1870501	-	375	WP_000340977.1	hypothetical protein	-
GBR75_RS08925	1870557..1870844	-	288	WP_160210530.1	hypothetical protein	-
GBR75_RS08930	1870891..1871043	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / chp / sak / sea	1861298..1928533	67235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T141892 WP_011447039.1 NZ_CP045468:c1868824-1868648 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T141892 NZ_CP060159:1161860-1162126 [Xylella fastidiosa subsp. fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT141892 NZ_CP045468:1868525-1868580 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin