Detailed information of TA system TA141890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 178399..179056
• Replicon: plasmid pSal-3973_DHA_CMY
• Accession: NZ_CP045467
• Organism: Salmonella enterica subsp. enterica serovar Anatum strain Sal-3973

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: GER12_RS23460
• Protein ID: WP_000270043.1
• Coordinates: 178399..178749 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: GER12_RS23465
• Protein ID: WP_000124640.1
• Coordinates: 178754..179056 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GER12_RS23410	173710..173889	+	180	Protein_207	helix-turn-helix transcriptional regulator	-
GER12_RS23415	173954..174658	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
GER12_RS23420	174873..175370	-	498	WP_000062185.1	hypothetical protein	-
GER12_RS23425	175373..175861	-	489	WP_001273096.1	DUF1643 domain-containing protein	-
GER12_RS23430	175958..176293	+	336	WP_000683476.1	hypothetical protein	-
GER12_RS23435	176308..176778	-	471	WP_001281821.1	hypothetical protein	-
GER12_RS23440	176771..177142	-	372	WP_000516916.1	hypothetical protein	-
GER12_RS23445	177153..177347	-	195	WP_000343597.1	hypothetical protein	-
GER12_RS23455	177688..178236	-	549	WP_001061574.1	transcriptional regulator	-
GER12_RS23460	178399..178749	+	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GER12_RS23465	178754..179056	+	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
GER12_RS23470	179083..179376	-	294	WP_001239997.1	chromosome segregation protein ParM	-
GER12_RS23475	179464..179736	-	273	WP_001043047.1	HU family DNA-binding protein	-
GER12_RS23480	179794..180321	-	528	WP_001236377.1	thermonuclease family protein	-
GER12_RS23490	180552..181409	-	858	WP_001167032.1	hypothetical protein	-
GER12_RS23495	181396..181626	-	231	WP_000972663.1	hypothetical protein	-
GER12_RS23500	181626..182144	-	519	WP_000210756.1	nitrite reductase	-
GER12_RS23505	182141..182587	-	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
GER12_RS23510	182587..182946	-	360	WP_000422768.1	hypothetical protein	-
GER12_RS23515	183003..183431	-	429	WP_000591074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..195486	195486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-85)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-93)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T141890 WP_000270043.1 NZ_CP045467:178399-178749 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T141890 NZ_CP060159:1158020-1158316 [Xylella fastidiosa subsp. fastidiosa]
ATGGTCGAACTCATCAAAACCAGCACTTTTGATGCTTGGATAAACAGCTTACGTGACCGCAAAGCAGCCGCCAGAATTCA
AGCGCGTCTTGATCGGCTCGCACTTGGCAATCCCGGCGACGTGAAGCCTGTGGGTGCTGGCATCTCAGAAATGAGGATCG
ACCATGGGCCCGGATATCGGATCTATTTTATGAAGCATGGTGCAGTACTGATTCTCTTACTTTGCGGTGGCGATAAATCG
TCACAAGTACGAGATATAGAGCAGGCTAAGGCACTGGCTGCACTGTGGAAGGATTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>AT141890 WP_000124640.1 NZ_CP045467:178754-179056 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>AT141890 NZ_CP060159:1158320-1158625 [Xylella fastidiosa subsp. fastidiosa]
ATGAATAATGAGACTTTTAGTCGATACGACACCGCTGACTATCTCAAAACCGAAGAAGATATTGCGGCTTATATGGAAGC
CGTCATGGAAGAAGGTGGTAGGGATAATCCTGCTTTTATTGCACGGGCACTTGGTGCTGTCGCTCGTGCTCGTAATTTAA
GTCAGCTTGCTCGTGACGTTGGCATGTCCAGGCAAGGACTAGACAAGGCACTCTCTAACGACGGCAACCCAAGCTTCTCA
ACCATCTTAAAAGTGGCTAAAGCGCTTGGTTTACGGATGTCATTCACACCTTCCTCTATGAGTTAA

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9